Thursday, December 5, 2013

UK FSA Cleveland Meat Company prosecution on failure to remove specified risk material (SRM) per TSE prion regulation

Last updated on 5 December 2013


Cleveland Meat Company prosecution


The FSA has welcomed the successful prosecution of the Cleveland Meat Company Ltd for breaches of food safety regulations. The company has been ordered to pay more than £27,000 in fines and prosecution costs after being found guilty on 12 charges. It entered a guilty plea on a 13th charge during the course of the hearing.


The FSA brought the prosecution against the Cleveland Meat Company after FSA staff identified breaches of the regulations, which are in place to prevent potential consumer exposure to BSE. These breaches included the failure to remove specified risk material (SRM) from a sheep carcass. SRM are the parts of the animal most likely to carry infectivity.


Andrew Rhodes, Chief Operating Officer of the FSA, said: 'We are pleased with the successful conclusion of this prosecution. These regulations are in place to keep the public safe and the FSA’s job is to ensure they are enforced properly across the country. Where companies are not meeting their responsibilities we will take action.'





THAT AIN’T BAD, only $27,000 fine for exposing the consumers to a disease that is 100% fatal, once clinical, and really, no way to trace the potential iatrogenic TSE there from to humans. all iatrogenic CJD is, is sporadic CJD, until the iatrogenic event that took place is identified, confirmed, and then put in the academic domain, and that rarely ever happens $$$...TSS



why do we not want to do TSE transmission studies on chimpanzees $


*** 5. A positive result from a chimpanzee challenged severly would likely create alarm in some circles even if the result could not be interpreted for man. I have a view that all these agents could be transmitted provided a large enough dose by appropriate routes was given and the animals kept long enough. Until the mechanisms of the species barrier are more clearly understood it might be best to retain that hypothesis.








1: J Infect Dis 1980 Aug;142(2):205-8


Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates.


Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.


Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of sheep and goats were transmitted to squirrel monkeys (Saimiri sciureus) that were exposed to the infectious agents only by their nonforced consumption of known infectious tissues. The asymptomatic incubation period in the one monkey exposed to the virus of kuru was 36 months; that in the two monkeys exposed to the virus of Creutzfeldt-Jakob disease was 23 and 27 months, respectively; and that in the two monkeys exposed to the virus of scrapie was 25 and 32 months, respectively. Careful physical examination of the buccal cavities of all of the monkeys failed to reveal signs or oral lesions. One additional monkey similarly exposed to kuru has remained asymptomatic during the 39 months that it has been under observation.




*** The successful transmission of kuru, Creutzfeldt-Jakob disease, and scrapie by natural feeding to squirrel monkeys that we have reported provides further grounds for concern that scrapie-infected meat may occasionally give rise in humans to Creutzfeldt-Jakob disease.


PMID: 6997404




Recently the question has again been brought up as to whether scrapie is transmissible to man. This has followed reports that the disease has been transmitted to primates. One particularly lurid speculation (Gajdusek 1977) conjectures that the agents of scrapie, kuru, Creutzfeldt-Jakob disease and transmissible encephalopathy of mink are varieties of a single "virus". The U.S. Department of Agriculture concluded that it could "no longer justify or permit scrapie-blood line and scrapie-exposed sheep and goats to be processed for human or animal food at slaughter or rendering plants" (ARC 84/77)" The problem is emphasised by the finding that some strains of scrapie produce lesions identical to the once which characterise the human dementias"


Whether true or not. the hypothesis that these agents might be transmissible to man raises two considerations. First, the safety of laboratory personnel requires prompt attention. Second, action such as the "scorched meat" policy of USDA makes the solution of the acrapie problem urgent if the sheep industry is not to suffer grievously.








Nature. 1972 Mar 10;236(5341):73-4.


Transmission of scrapie to the cynomolgus monkey (Macaca fascicularis).


Gibbs CJ Jr, Gajdusek DC.


Nature 236, 73 - 74 (10 March 1972); doi:10.1038/236073a0


Transmission of Scrapie to the Cynomolgus Monkey (Macaca fascicularis)




National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland


SCRAPIE has been transmitted to the cynomolgus, or crab-eating, monkey (Macaca fascicularis) with an incubation period of more than 5 yr from the time of intracerebral inoculation of scrapie-infected mouse brain. The animal developed a chronic central nervous system degeneration, with ataxia, tremor and myoclonus with associated severe scrapie-like pathology of intensive astroglial hypertrophy and proliferation, neuronal vacuolation and status spongiosus of grey matter. The strain of scrapie virus used was the eighth passage in Swiss mice (NIH) of a Compton strain of scrapie obtained as ninth intracerebral passage of the agent in goat brain, from Dr R. L. Chandler (ARC, Compton, Berkshire).





Wednesday, February 16, 2011










Monday, December 02, 2013


A parliamentary inquiry has been launched today into the safety of blood, tissue and organ screening following fears that vCJD – the human form of ‘mad cow’ disease – may be being spread by medical procedures




Tuesday, November 5, 2013


Food Standards Agency FSA 13/11/05 Open Board – 05 November 2013 BSE




Thursday, June 6, 2013






Friday, October 25, 2013


UK FSA TSE BSE Board meeting agenda: 5 November 2013




Wednesday, March 27, 2013


U-turn considered on European PAP animal feed ban 27 Mar 2013 News




Tuesday, March 5, 2013


FSA notified of BSE control breaches again and again 5 March 2013




Thursday, January 17, 2013


FSA notified of two breaches of BSE testing regulations 14 January 2013




Food Standards Agency FSA 13/01/01 Open Board – 22 January 2013







12. The Deputy Chair declared an interest as an owner of a small farm, but had no livestock. The Chair agreed that this would not improperly influence the Deputy Chair’s contributions to the discussion.


13. The Chair welcomed Alison Gleadle, FSA Director of Food Safety, David Carruthers, FSA Head of Meat Hygiene and TSE Policy Branch and Alick Simmons, Deputy Chief Veterinary Officer, Defra to the meeting. Alison Gleadle explained that the critical controls to protect human health and prevent a recurrence of BSE were those associated with the removal of Specified Risk Material (SRM) from carcases and the control of feed stuffs. The current proposal to stop BSE testing healthy slaughter cattle was based on European Food Safety Authority (EFSA) advice and relates to surveillance rather than consumer protection. This advice was consistent with previous advice from the Spongiform Encephalopathy Advisory Committee (SEAC) that any change in BSE incidence is most likely to be detected in at risk cattle. The letter from the Chief Medical Officer also agreed with this assessment. No change was proposed to the SRM or feed ban controls. Alison Gleadle assured the Board that if there were any unexpected changes in BSE levels or deterioration in the epidemiological situation, the Board would be informed.


14. Alick Simmons said Defra, as the Department responsible for overseeing the surveillance system, was committed to managing the risk to public health on a proportionate basis.


15. A Board member agreed the science supported the recommendation in the paper but wanted assurance that sufficient testing would remain in place to spot any re-emergence of BSE and wanted to know if it would take longer to detect an increase. Alick Simmons said this would not be the beginning of the end of monitoring. Internationally the UK has controlled risk status. It would take 11 years after the birth of the last BSE case before the UK achieved negligible risk status and could


Food Standards Agency FSA 13/01/01 Open Board – 22 January 2013 4


reduce the controls. The current sensitive controls made predictions of re-emergence easier and would remain in place. There could be a change in the speed with which a re-emergence of the disease could be detected but as long as the SRM and feed controls remained in place the effects of any delay would be significantly mitigated.


16. The Chair of the Scottish Food Advisory Committee (SFAC) said the Committee agreed with the recommendation but it was crucial that the two controls (feed ban and SRM) remained in place. He asked if the FSA would have to wait 17 years to detect a re-emergence or if the continued testing of at-risk cattle would detect it before then. Alick Simmons said he would expect to see any re-emergence in at-risk cattle. The results of the monitoring undertaken by Defra were published. AHVLA run a model every year on the data so any change in the level of BSE detected would come to the FSA’s attention as soon as that data was reported.


17. The Chair of the Welsh Food Advisory Committee (WFAC) said the Committee supported moving to the modified regime but it was a pre-requisite that the controls (feed ban and SRM) remained in place and regular reports on the effectiveness of the monitoring system were provided. These reports would be expected to include information on the feed ban although the enforcement of it is not part of the FSA’s remit.


18. On behalf of the Chair of the Northern Ireland Food Advisory Committee (NIFAC), the Chair said NIFAC also sought reassurance on the integrity of the surveillance of fallen and at-risk cattle.


19. The Deputy Chair said that while the FSA would be involved in any changes to the TSE Road map, it would not be involved in any changes to animal health surveillance and stressed that communication between Defra and the FSA on this latter point would be crucial. The Chief Executive drew the Board’s attention to the letter from Peter Unwin, Director General of Policy Delivery at Defra, which states that the FSA’s advice will be sought on the food safety implications of any proposals to change the BSE testing requirements.


20. The Deputy Chair said Bulgaria and Romania were high risk countries and asked if traceability systems existed to cope with a two tier system. Alick Simmons said that Romania and Bulgaria were not necessarily higher risk but as their controls had been in place for a shorter period, they could not yet move to a lower level of surveillance. He said there were statutory requirements on surveillance of foreign stock, on diseases other than BSE and additional tests for new and emerging diseases. Defra expected to start a consultation on 13 December 2012 to reconfigure the surveillance system for new and emerging diseases in England and Wales. Alick Simmons invited Board members to attend the AHVLA meetings as part of their consultation on changes to wider surveillance systems for new and emerging diseases.


Action: Deputy Chief Veterinary Officer Food Standards Agency FSA 13/01/01 Open Board – 22 January 2013


5 21. A Board member suggested adding the following wording to the FSA advice to Ministers: “while continuing to test all “risk cattle” aged over 48 months and subject to maintaining the ban on feeding animal protein to farmed animals and the removal of specified risk material (SRM).”


22. The Chair said the risk to consumers of stopping BSE testing of all healthy cattle aged over 72 months was negligible and the food supply chain would continue to be protected with the ban on animal protein in animal feed and the removal of specified risk material (SRM). With no case of BSE in healthy










Director of Food Safety


The Board should review a report on the results of the BSE monitoring system and the effectiveness of enforcement of the feed and SRM controls six months after current levels of BSE testing are reduced; a second report after another six months; and then a report annually.


Nov 2013


This has been noted and placed on the future agenda plan.





Citizens Forums are the main mechanism for direct engagement with consumers across the UK. Forums can either be a longer deliberative process where more information is required and consumers need time to think more widely about the issues. For other policy issues a shorter one-session discussion is used e.g. changes to BSE testing.


Locations are chosen to ensure ethnic diversity and consumers with non-English cultures are included. This involves selecting locations with rich ethnic diversity e.g. Birmingham, Bradford, Leicester and London. On some policy issues the closeness to agriculture or farming has made a difference to how consumers view particular challenges. Recent examples of this include Processed Animal Protein (PAP), EU Proposals on BSE Regulation and Consumer Attitudes to Raw Drinking Milk. Therefore ensuring consumers from areas that are more rurally located and not just cities or large towns has ensured the engagement does not become one dimensional.




breaches (UK)


In the period 1 April 2012 to 30 September 2012, 1,277,136 bovines were slaughtered for human consumption, with 5 breaches of BSE controls reported in the period. During Quarter 2 (July – September 2012) there were 4 breaches and 643,732 bovines were slaughtered for human consumption. None of these breaches were for bovines included in FSA checks. All specified risk material would have been removed from the animals at the time of processing (specified risk material is the parts of an animal likely to contain any infectivity in the unlikely event that the animal should have BSE).






> This has been noted and placed on the future agenda plan.







TO STOP TESTING HEALTHY CATTLE FOR BSE TSE PRION DISEASE, all strains, it just seems so counter productive to me, and further risk spreading the BSE TSE prion agent even further, thus risking more humans...tss



“This research raises the possibility, which has been mentioned before, that apparently healthy cattle could harbour, but never show signs of, BSE.”




MRC-43-00 Issued: Monday, 28 August 2000




A team of researchers led by Professor John Collinge at the Medical Research Council Prion Unit1 report today in the Proceedings of the National Academy of Sciences, on new evidence for the existence of a ?sub-clinical? form of BSE in mice which was unknown until now.



"This is a timely and unexpected result, increasing what we know about prion disease. These new findings have important implications for those researching prion disease, those responsible for preventing infected material getting into the food chain and for those considering how best to safeguard health and reduce the risk that theoretically, prion disease could be contracted through medical and surgical procedures."




see full text ;




Neurobiology of Disease


Subclinical Bovine Spongiform Encephalopathy Infection in Transgenic Mice Expressing Porcine Prion Protein




Friday, December 21, 2012


Four BSE cases with an L-BSE molecular profile in cattle from Great Britain


Veterinary Record doi:10.1136/vr.101158 Paper




Monday, October 14, 2013


Researchers estimate one in 2,000 people in the UK carry variant CJD proteins




Tuesday, October 29, 2013






Wednesday, October 09, 2013






Thursday, October 10, 2013


CJD REPORT 1994 increased risk for consumption of veal and venison and lamb




Friday, August 16, 2013


*** Creutzfeldt-Jakob disease (CJD) biannual update August 2013 U.K. and Contaminated blood products induce a highly atypical prion disease devoid of PrPres in primates




WHAT about the sporadic CJD TSE proteins ?



WE now know that some cases of sporadic CJD are linked to atypical BSE and atypical Scrapie, so why are not MORE concerned about the sporadic CJD, and all it’s sub-types $$$



Creutzfeldt-Jakob Disease CJD cases rising North America updated report August 2013


*** Creutzfeldt-Jakob Disease CJD cases rising North America with Canada seeing an extreme increase of 48% between 2008 and 2010 ***




Sunday, October 13, 2013


CJD TSE Prion Disease Cases in Texas by Year, 2003-2012




Monday, September 02, 2013


Lessons from the response to the threat of transfusion-transmitted vCJD in Ireland




Saturday, November 2, 2013


Recommendation of the Swiss Expert Committee for Biosafety on the classification of activities using prion genes and prion protein January 2013




Wednesday, December 4, 2013


Bovine Spongiform Encephalopathy; Importation of Bovines and Bovine Products; Final Rule Federal Register / Vol. 78 , No. 233 / Wednesday, December 4, 2013


TO ALL IMPORTING COUNTRIES THAT IMPORTS FROM THE USA, BE WARNED, NEW MAD COW BSE REGULATIONS USDA, AND OIE, not worth the paper the regulations were wrote on, kind of like the mad cow feed ban of August 1997, nothing but ink on paper $$$


full text ;




Thursday, December 05, 2013


National Scrapie Eradication Program October 2013 Monthly Report Fiscal Year 2014 TSE PRION REPORT






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