Friday, August 3, 2012

SUMMARY REPORT CALIFORNIA BOVINE SPONGIFORM ENCEPHALOPATHY CASE INVESTIGATION JULY 2012

SUMMARY REPORT CALIFORNIA BOVINE SPONGIFORM ENCEPHALOPATHY CASE INVESTIGATION JULY 2012




Summary Report BSE 2012


Executive Summary


On April 24, 2012, the U.S. Department of Agriculture (USDA) announced a fourth case of bovine spongiform encephalopathy (BSE) in the United States. The index animal was a 10 year 7 month-old Holstein cow from a central California dairy. The animal was sampled by a renderer contracted to collect samples as part of USDA’s ongoing BSE surveillance. Results from immunohistochemistry and Western blot tests at USDA’s National Veterinary Services Laboratories (NVSL) confirmed the animal positive for atypical BSE.


Two offspring of the index animal were designated as at-risk cattle. One was traced out-of-State and depopulated with “not detected” BSE test results. The other offspring was stillborn. The carcass of the index animal (along with approximately 90 other carcasses being held at the renderer’s transfer station), were disposed of in a landfill in accordance with all Federal, State and local regulations. The carcass of the index animal did not enter the human or animal food chain.


In conjunction with USDA’s investigation, the U.S. Department of Health and Human Services’ Food and Drug Administration (FDA) and the California Department of Food and Agriculture (CDFA) conducted an extensive feed investigation. Twelve feed suppliers were identified to the index premises; one of which was no longer in business. The remaining 11 were found to be in compliance with FDA and CDFA regulations and requirements.



SEE FULL INVESTIGATION HERE ;









***Also, a link is suspected between atypical BSE and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases constitute an unforeseen first threat that could sharply modify the European approach to prion diseases.


Second threat


snip...






MAD COW USDA ATYPICAL L-TYPE BASE BSE, the rest of the story...


***Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model






***Infectivity in skeletal muscle of BASE-infected cattle






***feedstuffs- It also suggests a similar cause or source for atypical BSE in these countries.






***Also, a link is suspected between atypical BSE and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans.






The present study demonstrated successful intraspecies transmission of H-type BSE to cattle and the distribution and immunolabeling patterns of PrPSc in the brain of the H-type BSE-challenged cattle. TSE agent virulence can be minimally defined by oral transmission of different TSE agents (C-type, L-type, and H-type BSE agents) [59]. Oral transmission studies with H-type BSEinfected cattle have been initiated and are underway to provide information regarding the extent of similarity in the immunohistochemical and molecular features before and after transmission.


In addition, the present data will support risk assessments in some peripheral tissues derived from cattle affected with H-type BSE.






in the url that follows, I have posted


SRM breaches first, as late as 2011.


then


MAD COW FEED BAN BREACHES AND TONNAGES OF MAD COW FEED IN COMMERCE up until 2007, when they ceased posting them.


then,


MAD COW SURVEILLANCE BREACHES.


Friday, May 18, 2012


Update from APHIS Regarding a Detection of Bovine Spongiform Encephalopathy (BSE) in the United States Friday May 18, 2012






Wednesday, May 30, 2012


PO-028: Oral transmission of L-type bovine spongiform encephalopathy (L-BSE) in primate model Microcebus murinus






Monday, June 18, 2012


R-CALF Submits Incomplete Comments Under Protest in Bizarre Rulemaking “Bovine Spongiform Encephalopathy; Importation of Bovines and Bovine Products”








Monday, July 23, 2012


The National Prion Disease Pathology Surveillance Center July 2012






Wednesday, June 27, 2012


First US BSE Case Since 2006 Underscores Need for Vigilance


Neurology Today 21 June 2012






Tuesday, June 26, 2012


Creutzfeldt Jakob Disease Human TSE report update North America, Canada, Mexico, and USDA PRION UNIT as of May 18, 2012


type determination pending Creutzfeldt Jakob Disease (tdpCJD), is on the rise in Canada and the USA






TSS


From: oie-info-web@oie.int Sent: Friday, April 27, 2012 2:47 AM To: OIE Mailing List Subject: USA 27-04-12 OIE Alert - Alerta - Alerte - Bovine spongiform encephalopathy - Encéphalopathie spongiforme bovine - Encefalopatía espongiforme bovina


English PDF reports Français Rapports PDF Español informes PDF


Bovine spongiform encephalopathy, United States of America


Information received on 26/04/2012 from Dr John Clifford, Deputy Administrator, Animal and Plant Health Inspection Service, United States Department of Agriculture, Washington, United States of America


Summary


Report type Immediate notification Start date 19/04/2012 Date of first confirmation of the event 23/04/2012 Report date 26/04/2012 Date submitted to OIE 26/04/2012 Reason for notification Reoccurrence of a listed disease Date of previous occurrence 2006 Manifestation of disease Sub-clinical infection Causal agent Prion (atypical BSE) Nature of diagnosis Laboratory (advanced) This event pertains to the whole country


New outbreaks Summary of outbreaks Total outbreaks: 1 Location(s) CALIFORNIA (Tulare, County, Tulare, County) Total animals affected Species Susceptible Cases Deaths Destroyed Slaughtered Cattle 1 1 0 Outbreak statistics Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost* Cattle ** ** ** **


* Removed from the susceptible population through death, destruction and/or slaughter ** Not calculated because of missing information


Epidemiology Source of the outbreak(s) or origin of infection Unknown or inconclusive Random mutation Epidemiological comments As part of the United States targeted bovine spongiform encephalopathy (BSE) surveillance system a case of BSE classified as atypical was identified in a dead dairy cow that was to be rendered. The dead animal’s carcass will be destroyed. • The cow was culled due to lameness. • The identified animal was never presented for slaughter for human consumption, did not enter food supply channels, and at no time presented any risk to human health. • An epidemiological investigation into the incident has been initiated. • Movement controls have been placed on the index premises.


Control measures Measures applied Quarantine Screening No vaccination No treatment of affected animals Measures to be applied No other measures


Diagnostic test results Laboratory name and type University of California (Local laboratory) Tests and results Species Test Test date Result Cattle enzyme-linked immunosorbent assay (ELISA) 19/04/2012 Doubtful (uncertain) Laboratory name and type National Veterinary Services Laboratories (NVSL) (National laboratory) Tests and results Species Test Test date Result Cattle enzyme-linked immunosorbent assay (ELISA) 21/04/2012 Doubtful (uncertain) Cattle immunohistochemical test 23/04/2012 Positive Cattle western blotting 23/04/2012 Positive


Future Reporting The event is continuing. Weekly follow-up reports will be submitted.




Encefalopatía espongiforme bovina, Estados Unidos de América


Información recibida el 26/04/2012 desde Dr John Clifford, Deputy Administrator, Animal and Plant Health Inspection Service, United States Department of Agriculture, Washington, Estados Unidos de América


Resumen


Tipo de informe Notificación inmediata Fecha de inicio 19/04/2012 Fecha de la primera confirmación del evento 23/04/2012 Fecha del informe 26/04/2012 Fecha de envio del informe a la OIE 26/04/2012 Motivo de la notificación Reaparición de una enfermedad de la Lista de la OIE Fecha de la anterior aparición de la enfermedad 2006 Manifestación de la enfermedad Infección sub-clínica Agente causal Prion (EEB atípica) Naturaleza del diagnóstico Pruebas de diagnóstico de laboratorio avanzadas (ej. virología, microscopía electrónica, biología molecular e inmunología) Este evento concierne todo el país


Nuevos focos Resumen de los focos Número total de focos: 1 Localización CALIFORNIA (Condado de Tulare, Tulare, County) Número total de animales afectados Especies Susceptibles Casos Muertos Destruidos Sacrificados Bovinos 1 1 0 Estadística del foco Especies Tasa de morbilidad aparente Tasa de mortalidad aparente Tasa de fatalidad aparente Proporción de animales susceptibles perdidos* Bovinos ** ** ** **


* Descontados de la población susceptible a raíz de su muerte, destrucción o sacrificio ** No calculado por falta de datos


Epidemiología Fuente del o de los focos u origen de la infección Desconocida o no concluyente Mutación aleatoria Otros detalles epidemiológicos / comentarios Dentro del sistema de vigilancia específica de los Estados Unidos para la encefalopatía espongiforme bovina (EEB), se ha identificado un caso de EEB clasificado como atípico en una vaca lechera muerta que debía ser destruida. El cuerpo del animal muerto será destruido. - La vaca había sido sacrificada porque cojeaba. - El animal identificado nunca fue enviado al matadero para consumo humano, no entró en la cadena alimentaria y, en ningún momento, supuso un riesgo para la salud humana. - Se ha emprendido una investigación epidemiológica sobre el evento. - Se han instaurado medidas de restricción de los desplazamientos en la explotación de origen.


Medidas de Control Medidas implementadas Cuarentena Tamizaje Vacunación: no Ningún tratamiento de los animales afectados Medidas para implementar Ninguna otra medida


Resultados de las pruebas diagnósticas Nombre y tipo de laboratorio Universidad de California (Laboratorio local) Pruebas y resultados Especies Prueba Fecha de la prueba Resultados Bovinos prueba inmunoenzimática (ELISA) 19/04/2012 Dudoso Nombre y tipo de laboratorio Laboratorio de los Servicios veterinarios nacionales (NVSL) (Laboratorio nacional) Pruebas y resultados Especies Prueba Fecha de la prueba Resultados Bovinos examen inmunohistoquímico 23/04/2012 Positivo Bovinos prueba de inmunodetección 23/04/2012 Positivo Bovinos prueba inmunoenzimática (ELISA) 21/04/2012 Dudoso


Informes futuros El episodio continúa. Informes de seguimiento semanales serán enviados




Encéphalopathie spongiforme bovine, Etats-Unis d'Amérique


Information reçue le 26/04/2012 de Dr John Clifford, Deputy Administrator, Animal and Plant Health Inspection Service, United States Department of Agriculture, Washington, Etats-Unis d'Amérique


Résumé


Type de rapport Notification immédiate Date de début 19/04/2012 Date de première confirmation de l´événement 23/04/2012 Date du rapport 26/04/2012 Date d'envoi à l'OIE 26/04/2012 Raison de notification Réapparition d’une maladie appartenant à la liste de l'OIE Date de la précédente apparition de la maladie 2006 Manifestation de la maladie Infection sub-clinique Agent causal Prión (ESB atypique) Nature du diagnostic Tests approfondis en laboratoire (i.e. virologie, microscopie électronique, biologie moléculaire, immunologie) Cet événement se rapporte à tout le pays


Nouveaux foyers Récapitulatif des foyers Nombre total de foyers : 1 Localisation(s) CALIFORNIA (Comté de Tulare, Tulare, County) Nombre total d'animaux atteints Espèce(s) Sensibles Cas Morts Détruits Abattus Bovins 1 1 0 Statistiques sur le foyer Espèce(s) Taux de morbidité apparent Taux de mortalité apparent Taux de fatalité apparent Proportion d'animaux sensibles perdus* Bovins ** ** ** **


* Soustraits de la population sensible suite à la mort, à l´abattage et/ou à la destruction ** Non calculé par manque de données


Epidémiologie Source du/des foyer(s) ou origine de l´infection Inconnue ou incertaine Mutation aléatoire Autres renseignements épidémiologiques / Commentaires Dans le cadre du système de surveillance spécifique des États-Unis pour l’encéphalopathie spongiforme bovine (ESB), un cas d’ESB classifié comme atypique a été identifié chez une vache laitière morte devant être équarrie. La carcasse de l’animal mort sera détruite. - La vache avait été abattue car elle boitait. - L’animal identifié n’a jamais été envoyé à l’abattage pour consommation par l’homme, il n’a pas été introduit dans la chaine alimentaire et, à aucun moment, il n’a présenté aucun risque pour la santé humaine. - Une enquête épidémiologique sur l’événement a été lancée. - Des mesures de restriction des déplacements ont été mises en œuvre sur l’élevage d’origine.


Mesures de lutte Mesure de lutte appliquées Quarantaine Dépistage Pas de vaccination Aucun traitement des animaux atteints Mesures à appliquer Aucune autre mesure


Résultats des tests de diagnostics Nom du laboratoire et type Université de Californie (Laboratoire local) Tests et résultats Espèce(s) Test Date du test Résultat Bovins méthode de dosage immuno-enzymatique (ELISA) 19/04/2012 Douteux Nom du laboratoire et type Laboratoire des Services vétérinaires nationaux (NVSL) (Laboratoire national) Tests et résultats Espèce(s) Test Date du test Résultat Bovins examen immunohistochimique 23/04/2012 Positif Bovins méthode de dosage immuno-enzymatique (ELISA) 21/04/2012 Douteux Bovins western blot 23/04/2012 Positif


Rapports futurs Cet événement se poursuit. Des rapports de suivi hebdomadaires devront être envoyés.




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Tuesday, July 17, 2012



O.I.E. BSE, CWD, SCRAPIE, TSE PRION DISEASE Final Report of the 80th General Session, 20 - 25 May 2012









TSS


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