Tuesday, October 29, 2013

Risk of Prion Disease Transmission through Bovine-Derived Bone Substitutes: A Systematic Review

Risk of Prion Disease Transmission through Bovine-Derived Bone Substitutes: A Systematic Review

 

Yeoungsug Kim DDS1, Hessam Nowzari DDS; PhD2,*, Sandra K. Rich MPH, PhD3

 

Article first published online: 15 DEC 2011

 

DOI: 10.1111/j.1708-8208.2011.00407.x

 

© 2011 Wiley Periodicals, Inc.

 

Issue

 

Clinical Implant Dentistry and Related Research

 

Clinical Implant Dentistry and Related Research

 

Volume 15, Issue 5, pages 645–653, October 2013

 

Additional Information(Hide All)

 

How to CiteAuthor InformationPublication History

 

 How to Cite

 

Kim, Y., Nowzari, H. and Rich, S. K. (2013), Risk of Prion Disease Transmission through Bovine-Derived Bone Substitutes: A Systematic Review. Clinical Implant Dentistry and Related Research, 15: 645–653. doi: 10.1111/j.1708-8208.2011.00407.x

 

Author Information 1 Resident, Advanced Education in Periodontics Program, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA

 

2 professor, Clinical Dentistry and director, Advanced Education in Periodontics Program, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA

 

3 associate professor, Advanced Education in Periodontics Program, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA

 

*Dr. Hessam Nowzari, Herman Ostrow School of Dentistry, University of Southern California, Norris Dental Science Center-DEN, 925W. 34th Street, Room 119, Los Angeles, CA 90089-0641, USA; e-mail: nowzari@usc.edu

 

Publication History Issue published online: 7 OCT 2013 Article first published online: 15 DEC 2011

 

Keywords:

 

anorganic bovine bone substitutes; BSE diagnostic test; BSE prion inactivation; BSE prion infectivity; protein; PrP(27-30); PrPSc

 

ABSTRACT

 

Background: Despite the causal association between variant Creutzfeldt – Jakob disease and bovine spongiform encephalopathy (BSE), bovine origin graft materials are widely used during dental surgical procedures. The aim of this study was to assess the risk of BSE transmission through anorganic bovine bone substitutes.

 

Methods: Electronic database of MEDLINE was searched to identify relevant studies regarding our focused questions, presence of BSE prion infectivity in raw bovine bone, BSE prion inactivation by bone substitute manufacturing process, protein contents in anorganic bovine bone substitutes, and validity of current BSE diagnostic methods. Search terms yielded 1,704 titles. After title/abstract screening and duplicates removal, 36 full-text articles were screened for inclusion.

 

Results: A total of 16 studies were included in the final analysis. No eligible studies were identified regarding the efficacy of BSE prion inactivation by the treatments used for anorganic bovine bone manufacturing. BSE infectivity and PrPSc, pathological prion, were detected in bovine bone marrow and serum samples. Proteins were detected in Tutoplast® (bovine), Bio-Oss®, and tibia samples treated at the similar condition for Bio-Oss deproteinization. Inconsistent results of different BSE diagnostic tests were not unusual findings (Iwata et al. 2006; Arnold et al. 2007; Murayama et al. 2010), and a study by Balkema-Buschmann and colleagues showed an apparent discrepancy between BSE infectivity and detection of PrP(27-30), the current surrogate marker for prion disease infectivity.

 

Conclusion: This review indicates that bovine-derived graft biomaterials may carry a risk of prion transmission to patients.

 

 


 


Thursday, January 17, 2013


TSE guidance, surgical, dental, blood risk factors, Part 4 Infection control of CJD, vCJD and other human prion diseases in healthcare and community settings (updated January 2013)


http://transmissiblespongiformencephalopathy.blogspot.com/2013/01/tse-guidance-surgical-dental-blood-risk.html

 

Tuesday, October 29, 2013

 

VARIANT CJD PRESENTS DIFFERENTLY IN OLDER PATIENTS

 


 

Monday, October 14, 2013

Researchers estimate one in 2,000 people in the UK carry variant CJD proteins


http://creutzfeldt-jakob-disease.blogspot.com/2013/10/researchers-estimate-one-in-2000-people.html


WHAT about the sporadic CJD TSE proteins ?
WE now know that some cases of sporadic CJD are linked to atypical BSE and atypical Scrapie, so why are not MORE concerned about the sporadic CJD, and all it’s sub-types $$$
Sunday, August 11, 2013

Creutzfeldt-Jakob Disease CJD cases rising North America updated report August 2013

Creutzfeldt-Jakob Disease CJD cases rising North America with Canada seeing an extreme increase of 48% between 2008 and 2010


http://creutzfeldt-jakob-disease.blogspot.com/2013/08/creutzfeldt-jakob-disease-cjd-cases.html



Sunday, October 13, 2013

CJD TSE Prion Disease Cases in Texas by Year, 2003-2012


http://creutzfeldt-jakob-disease.blogspot.com/2013/10/cjd-tse-prion-disease-cases-in-texas-by.html


Wednesday, September 25, 2013

Cleaning, disinfection and sterilization of surface prion contamination


http://creutzfeldt-jakob-disease.blogspot.com/2013/09/cleaning-disinfection-and-sterilization.html


 

 
TSS

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