From: Terry S. Singeltary Sr.
Sent: Wednesday, November 27, 2013 2:06 PM
To: BSE-L BSE-L
Subject: NHS failed to sterilise surgical instruments contaminated
with 'mad cow' disease
NHS failed to sterilise surgical instruments contaminated with 'mad cow'
disease
Regular sterilisation procedure wasn't suitable for the task, says leading
specialist Steve Connor Author Biography Science Editor Wednesday 27 November
2013
The NHS has failed to use an effective method of sterilising surgical
instruments contaminated with the human form of “mad cow” disease because it did
not fit in with its established washing procedures, a leading specialist in
variant Creutzfeldt-Jakob disease (vCJD) claimed yesterday.
The result is that hundreds of people have had their lives blighted by
surgery performed with instruments possibly contaminated the prion protein
responsible for vCJD said Professor John Collinge, director of the Medical
Research Council’s Prion Unit at University College London.
Professor Collinge led one of a number of research groups that came up with
novel ways of destroying the lethal prion protein, which sticks to the stainless
steel of surgical instruments like superglue and can survive the high
temperatures of hospital autoclaves.
However, in evidence to the House of Commons science and technology
committee, Professor Collinge said that he was astonished and disappointed that
the Department of Health and the NHS failed to adopt any of the suggestions for
decontaminating surgical instruments.
“The solution we developed was a combination of enzymes and detergents, if
you like a sort of bespoke biological washing powder which very effectively
prion-decontaminated metal surfaces,” Professor Collinge said.
It was one of several decontamination procedures developed by a number of
research groups sponsored by the health department over a decade ago to find
ways of making surgical instruments safe, he said.
“Neither this nor the other products that were available – I think there
were three – have ever been taken up by the NHS. They simply haven’t been used.
These issues have been bounced around various committees to my and other
peoples’ great frustration,” Professor Collinge said.
“It’s perhaps not surprising given that the NHS is notoriously resistant to
change and to introducing new methodologies,” he said.
“Absolutely nothing has happened despite all this research and all this
effort. Currently several hundred people have been notified that they have been
exposed to [potentially contaminated] surgical instruments,” he told the
committee.
“We’re blighting these peoples’ lives and all this has been avoidable for
some years by applying this research. I find it quite extraordinary that the
system just does not work,” he said.
“They’ve had to be notified that they’ve had a significant exposure to
prions because they are expected to take precautions. They are not allowed to be
blood donors and if they go on to have surgery they have to notify the surgeons
that they are high risk individuals.
“Needless to say this has a major effect on their lives and needless to say
it makes me very angry because all of this was avoidable,” he added.
DuPont, an American chemicals company, worked out a way of manufacturing
Professor Collinge’s product as a 50C pre-soak for surgical instruments, but
because this would involve changing the standard procedures for how medical
devices were sterilised, NHS hospitals refused to adopt it, Professor Collinge
claimed.
“What we had developed was seen to be inconvenient…The NHS didn’t buy a
single unit of the product so was it surprising that the manufacturer just
walked away?” he said.
“It was extraordinary [that] it was discussed in I don’t know how many
committees and subcommittees when patients are being put in this position and
having their lives blighted. It’s disgraceful,” he told the committee.
About 200 hospital patients have been told that they have been exposed to
the vCJD prion through instruments that were used on other patients who
subsequently died of the brain disease. Three out of the 177 people in the UK
who have died of vCJD received contaminated blood, and the rest are assumed to
have been infected by meat or meat products contaminated with bovine spongiform
encephalopathy (BSE).
A spokesman for the Department of Health said that Professor Collinge’s
research group has received £18m for various research projects and that DuPont’s
prion inactivation product has been reviewed twice by Public Health England’s
Rapid Review Panel, which established “gaps” in DuPont’s application.
Roland Salmon, the joint chairman of the government’s advisory
sub-committee on dangerous pathogens, defended the Department of Health’s stance
on introducing new ways of sterilising surgical instruments.
“I don’t think it’s fair on the department [of health] to say that nothing
was done…they did institute a number of improvements,” Dr Salmon said.
“It’s perfectly true they haven’t introduced specific products…the barrier
had been I’ve told with having a product composed in such a way that it can be
introduced into what is an industrialised process in a cycle,” he said.
How vCJD can be contracted
Almost all of the 177 cases of vCJD – the human form of “mad cow” disease –
have been contracted through eating contaminated meat or meat products before
the introduction of controls to limit the spread of bovine spongiform
encephalopathy (BSE) from cattle to people.
Three of these deaths, however, are believed to have resulted from blood
donors infected with vCJD, but showing no clinical symptoms. There is one
further case of a person who died of something else but who was shown at
post-mortem to be infected following a blood transfusion.
There are fears of secondary infections from asymptomatic carriers in the
population. Latest estimates suggest that up to one in 2,000 people in Britain
could be carriers of vCJD.
Because the prion protein responsible for vCJD is found in a wide range of
tissues, such as spleen, tonsils and appendix, the fear is that asymptomatic
carriers may spread the infection to others through contaminated surgical
instruments and blood donations.
AS usual, the media and the medical community missing the bigger picture.
this incident also risk the medical iatrogenic transmission of ALL TSE PRION
DISEASE, not just the UKBSEnvCJD only myth.
IN fact, there has never been an iatrogenic CJD event with nvCJD, except
the 5 documented iatrogenic events with blood and nvCJD.
all other medical, surgical transmission was all with sporadic CJD, which
is all iatrogenic CJD is, is sporadic CJD, until the the iatrogenic event is
documented, proven, and then placed in the academic domain.
kind regards,
terry
IATROGENIC
all iatrogenic cjd is, is sporadic CJD,
until route and source of the iatrogenic event that took place, is detected,
documented, placed in the academic domain as fact, and recorded, which happens
very seldom due to a lot of factors, besides the incubation period, and that be
mainly industry. kind of like asbestos and tobacco and the industry there from,
they knew in the early 1900’s that they both were killing, and they both had
long incubation, and somebody chose not to do anything about if for decades and
decades. kind of like what we have here with the TSE prion disease. $$$
> In 12 of 15 hospitals with
neurosurgical incidents, a decision was made to notify patients of their
potential exposure.
SO, X number of patients, from 3 hospitals,
where
''exposure to potentially CJD-contaminated
instruments ''
took place on these patients, the final
decision NOT to tell those folks about the potential exposure to the CJD TSE
prion
insane, thus, the TSE prion agent continues
to spread. ...please see further comments here ;
Saturday, November 16, 2013
Management of neurosurgical instruments and
patients exposed to creutzfeldt-jakob disease 2013 December
Infect Control Hosp Epidemiol.
Thursday, November 14, 2013
Prion diseases in humans: Oral and dental implications
Saturday, November 2, 2013
Recommendation of the Swiss Expert Committee
for Biosafety on the classification of activities using prion genes and prion
protein January 2013
BONE GRINDING, POTENTIAL AEROSOLS
TRANSMISSION, TSE PRION ???
Aerosols
Prion transmission is usually not considered to be airborne like influenza or chicken pox. But we and others recently have found that prions can also be efficiently transmitted to mice through aerosols [5], [6]. Although aerosol-transmitted prions have never been found under natural conditions, this finding highlights the necessity of revising the current prion-related biosafety guidelines and health standards in diagnostic and scientific laboratories being potentially confronted with prion-infected materials.
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002651
Prion transmission is usually not considered to be airborne like influenza or chicken pox. But we and others recently have found that prions can also be efficiently transmitted to mice through aerosols [5], [6]. Although aerosol-transmitted prions have never been found under natural conditions, this finding highlights the necessity of revising the current prion-related biosafety guidelines and health standards in diagnostic and scientific laboratories being potentially confronted with prion-infected materials.
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002651
Efficient mucosal transmission of CWD in deer has been demonstrated by oral,
nasal, aerosol, and indirect contact exposure.
*** PRION2013 ***
Sunday, August 25, 2013
Prion2013 Chronic Wasting Disease CWD risk factors, ***humans, domestic
cats, blood, and mother to offspring transmission
Thursday, December 29, 2011
Aerosols An underestimated vehicle for transmission of prion diseases?
PRION
www.landesbioscience.com
please see more on Aerosols and TSE prion disease here ;
http://transmissiblespongiformencephalopathy.blogspot.com/2011/12/aerosols-underestimated-vehicle-for.html
Monday, November 26, 2012
Aerosol Transmission of Chronic Wasting Disease in White-tailed Deer
http://chronic-wasting-disease.blogspot.com/2012/11/aerosol-transmission-of-chronic-wasting.html
Tuesday, November 26, 2013
Transmission of multiple system atrophy prions to transgenic mice
TSS
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