Friday, March 16, 2012

atypical BSE Mad cow disease found in Switzerland March 12, 2012

Monday, 12 March, 2012, 13:52

Mad cow strain found in Switzerland

The Federal Veterinary Office has confirmed one case of mad cow disease in the canton of Bern. The cow was slaughtered last month. The case was discovered as part of a monitoring programme implemented by Swiss authorities. According to vets the cow was not infected with a classical case of BSE, but rather an atypical strain. They say that means the disease was not triggered by a certain animal feed outlawed in 2005. The cow was imported to Switzerland in 2006. Until this case, no cows with BSE have been found in Switzerland since 2007. The Federal Veterinary Office confirms it may have found another one of these atypical cases but stresses this strain of disease is rare. BSE was first diagnosed in 1990, and since then 467 cows were diagnosed with it in Switzerland. No cases of the human strain have ever been detected here.

http://worldradio.ch/wrs/news/wrsnews/mad-cow-disease-strain-in-switzerland.shtml?29563





on the official government site for BSE, it’s not in English. ...TSS



BSE-Fall bei einer importierten Kuh

Bern, 12.03.2012 - Im Rahmen des offiziellen Überwachungsprogrammes wurde bei einer Kuh eines Betriebes im Kanton Bern BSE festgestellt. Analysen zeigen jedoch, dass es sich nicht um einen Fall von klassischer BSE handelt, sondern um eine sogenannte atypische BSE. Das Tier stammte aus Deutschland und wurde 2006 in die Schweiz importiert.

Der aktuelle Fall ändert nichts an der guten Lage bezüglich BSE in der Schweiz. Bis 2006 hatten sich die Fälle stark vermindert, zwischen 2007 und 2011 wurden überhaupt keine Fälle mehr diagnostiziert. Aber die letzten Fälle erinnern daran, dass wir trotz dieser vorteilhaften Situation doch vereinzelt mit Fällen von BSE rechnen müssen.

Die Diagnostik des Referenzlabors zeigt, dass es sich nicht um einen typischen Fall von BSE, sondern um einen sogenannt atypischen BSE-Fall handelt. Seit einigen Jahren werden in verschiedenen europäischen Ländern vereinzelt solche atypische Fälle von BSE festgestellt. Die Wissenschaftler glauben, dass diese Form der BSE möglicherweise eine sporadisch auftauchende Krankheit ist, die nicht auf infektiöses Material im Futter zurückzuführen ist. Im Gegensatz dazu werden die typischen BSE-Fälle durch infektiöses Material im Futter der Tiere verursacht.

Beim verseuchten Tier handelt es sich um eine bald 7-jährige Kuh welche im April 2005 in Deutschland geboren und im November 2006 in die Schweiz importiert wurde. Die Kuh musste wegen Festliegens nach der Geburt geschlachtet werden und wurde deshalb routinemässig labordiagnostisch untersucht. Dabei wurde BSE diagnostiziert. Seit dem ersten Schweizer Fall im Jahre 1990 wurden in der Schweiz insgesamt 467 BSE-Fälle gemeldet. Mit Ausnahme eines Falles in 2011 waren alle betroffenen Rinder vor dem totalen Tiermehlverfütterungsverbot vom Januar 2001 geboren worden. Seit 1990 war im Laufe der Jahre eine ganze Reihe von Massnahmen beschlossen und umgesetzt worden, um die Krankheit bei den Rindern einzudämmen. Es wurde in der Schweiz nie ein Fall der Variante der Creutzfeldt-Jakob-Erkrankung bei Menschen, die mit BSE in Verbindung gebracht wird, diagnostiziert.

Weitere Informationen finden sie auf der Web-Seite des BVET unter www.bvet.admin.ch > BSE. Sie finden dort insbesondere die Geschichte der getroffenen Massnahmen sowie Grafiken zur Entwicklung der BSE-Fälle in der Schweiz.

Adresse für Rückfragen: Regula Kennel, Bundesamt für Veterinärwesen Tel.: 031 323 84 96 Herausgeber: Bundesamt für VeterinärwesenInternet: http://www.bvet.admin.ch

Volltextsuche Suche

erweiterte Suche

Die Bundesbehörden der Schweizerischen Eidgenossenschaft webmaster@admin.ch | Rechtliche Grundlagen


http://www.news.admin.ch/message/index.html?lang=de&msg-id=43728






also, atypical bse and feed IS A FACTOR !


amplification and transmission of atypical BSE via feed is real, and can transmit just like the typical BSE did. any other statement is NOT based on science, but on TRADE $$$




P.9.21

Molecular characterization of BSE in Canada

Jianmin Yang1, Sandor Dudas2, Catherine Graham2, Markus Czub3, Tim McAllister1, Stefanie Czub1 1Agriculture and Agri-Food Canada Research Centre, Canada; 2National and OIE BSE Reference Laboratory, Canada; 3University of Calgary, Canada

Background: Three BSE types (classical and two atypical) have been identified on the basis of molecular characteristics of the misfolded protein associated with the disease. To date, each of these three types have been detected in Canadian cattle.

Objectives: This study was conducted to further characterize the 16 Canadian BSE cases based on the biochemical properties of there associated PrPres. Methods: Immuno-reactivity, molecular weight, glycoform profiles and relative proteinase K sensitivity of the PrPres from each of the 16 confirmed Canadian BSE cases was determined using modified Western blot analysis.

Results: Fourteen of the 16 Canadian BSE cases were C type, 1 was H type and 1 was L type. The Canadian H and L-type BSE cases exhibited size shifts and changes in glycosylation similar to other atypical BSE cases. PK digestion under mild and stringent conditions revealed a reduced protease resistance of the atypical cases compared to the C-type cases. N terminal- specific antibodies bound to PrPres from H type but not from C or L type. The C-terminal-specific antibodies resulted in a shift in the glycoform profile and detected a fourth band in the Canadian H-type BSE.

Discussion: The C, L and H type BSE cases in Canada exhibit molecular characteristics similar to those described for classical and atypical BSE cases from Europe and Japan. This supports the theory that the importation of BSE contaminated feedstuff is the source of C-type BSE in Canada.

*** It also suggests a similar cause or source for atypical BSE in these countries.



http://www.prion2009.com/sites/default/files/Prion2009_Book_of_Abstracts.pdf







Wednesday, March 7, 2012


The epidemiology of bovine spongiform encephalopathy in the Republic of Ireland before and after the reinforced feed ban


http://madcowfeed.blogspot.com/2012/03/epidemiology-of-bovine-spongiform.html







Wednesday, March 7, 2012


Case-control study of cases of bovine spongiform encephalopathy born after July 31, 1996 (BARB cases) in Great Britain


Veterinary Record doi:10.1136/vr.100097


http://madcowfeed.blogspot.com/2012/03/case-control-study-of-cases-of-bovine.html










Thursday, February 16, 2012

Bovine Spongiform Encephalopathy BSE

31 USA SENATORS ASK PRESIDENT OBAMA TO HELP SPREAD MAD COW DISEASE 2012


http://transmissiblespongiformencephalopathy.blogspot.com/2012/02/bovine-spongiform-encephalopathy-bse-31.html





Thursday, February 23, 2012

EIGHT FORMER SECRETARIES OF AGRICULTURE SPEAKING AT USDA'S 2012 AGRICULTURE OUTLOOK FORUM INDUCTED INTO USA MAD COW HALL OF SHAME


http://madcowusda.blogspot.com/2012/02/eight-former-secretaries-of-agriculture.html






Sunday, February 5, 2012 February 2012

Update on Feed Enforcement Activities to Limit the Spread of BSE


http://transmissiblespongiformencephalopathy.blogspot.com/2012/02/february-2012-update-on-feed.html








10,000,000+ LBS. of PROHIBITED BANNED MAD COW FEED I.E. BLOOD LACED MBM IN COMMERCE USA 2007

Date: March 21, 2007 at 2:27 pm PST

RECALLS AND FIELD CORRECTIONS: VETERINARY MEDICINES -- CLASS II

___________________________________

PRODUCT

Bulk cattle feed made with recalled Darling's 85% Blood Meal, Flash Dried, Recall # V-024-2007

CODE

Cattle feed delivered between 01/12/2007 and 01/26/2007

RECALLING FIRM/MANUFACTURER

Pfeiffer, Arno, Inc, Greenbush, WI. by conversation on February 5, 2007.

Firm initiated recall is ongoing.

REASON

Blood meal used to make cattle feed was recalled because it was cross- contaminated with prohibited bovine meat and bone meal that had been manufactured on common equipment and labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

42,090 lbs.

DISTRIBUTION

WI

___________________________________

PRODUCT

Custom dairy premix products: MNM ALL PURPOSE Pellet, HILLSIDE/CDL Prot- Buffer Meal, LEE, M.-CLOSE UP PX Pellet, HIGH DESERT/ GHC LACT Meal, TATARKA, M CUST PROT Meal, SUNRIDGE/CDL PROTEIN Blend, LOURENZO, K PVM DAIRY Meal, DOUBLE B DAIRY/GHC LAC Mineral, WEST PIONT/GHC CLOSEUP Mineral, WEST POINT/GHC LACT Meal, JENKS, J/COMPASS PROTEIN Meal, COPPINI - 8# SPECIAL DAIRY Mix, GULICK, L-LACT Meal (Bulk), TRIPLE J - PROTEIN/LACTATION, ROCK CREEK/GHC MILK Mineral, BETTENCOURT/GHC S.SIDE MK-MN, BETTENCOURT #1/GHC MILK MINR, V&C DAIRY/GHC LACT Meal, VEENSTRA, F/GHC LACT Meal, SMUTNY, A- BYPASS ML W/SMARTA, Recall # V-025-2007

CODE

The firm does not utilize a code - only shipping documentation with commodity and weights identified.

RECALLING FIRM/MANUFACTURER

Rangen, Inc, Buhl, ID, by letters on February 13 and 14, 2007. Firm initiated recall is complete.

REASON

Products manufactured from bulk feed containing blood meal that was cross contaminated with prohibited meat and bone meal and the labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

9,997,976 lbs.

DISTRIBUTION

ID and NV

END OF ENFORCEMENT REPORT FOR MARCH 21, 2007

http://www.fda.gov/bbs/topics/enforce/2007/ENF00996.html




NEW URL

http://www.fda.gov/Safety/Recalls/EnforcementReports/2007/ucm120446.htm






Thursday, March 19, 2009

MILLIONS AND MILLIONS OF POUNDS OF MAD COW FEED IN COMMERCE USA WITH ONGOING 12 YEARS OF DENIAL

http://madcowfeed.blogspot.com/2009/03/millions-and-millions-of-pounds-of-mad.html







Tuesday, March 2, 2010

Animal Proteins Prohibited in Ruminant Feed/Adulterated/Misbranded Rangen Inc 2/11/10 USA

http://madcowfeed.blogspot.com/2010/03/animal-proteins-prohibited-in-ruminant.html







Monday, March 1, 2010

ANIMAL PROTEIN I.E. MAD COW FEED IN COMMERCE A REVIEW 2010

http://madcowfeed.blogspot.com/2010/03/animal-protien-ie-mad-cow-feed-in.html











THANKS to the OIE and the USDA, and the BSE MRR policy, the legal trading of all strains of mad cow disease, more cases like this will come. ...TSS



Saturday, November 19, 2011

Novel Prion Protein in BSE-affected Cattle, Switzerland

http://transmissiblespongiformencephalopathy.blogspot.com/2011/11/novel-prion-protein-in-bse-affected.html





Friday, December 23, 2011

Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model

Volume 18, Number 1—January 2012 Dispatch

http://transmissiblespongiformencephalopathy.blogspot.com/2011/12/oral-transmission-of-l-type-bovine.html





Monday, October 10, 2011

EFSA Journal 2011 The European Response to BSE: A Success Story

snip...

EFSA and the European Centre for Disease Prevention and Control (ECDC) recently delivered a scientific opinion on any possible epidemiological or molecular association between TSEs in animals and humans (EFSA Panel on Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical BSE prions as the only TSE agents demonstrated to be zoonotic so far but the possibility that a small proportion of human cases so far classified as "sporadic" CJD are of zoonotic origin could not be excluded. Moreover, transmission experiments to non-human primates suggest that some TSE agents in addition to Classical BSE prions in cattle (namely L-type Atypical BSE, Classical BSE in sheep, transmissible mink encephalopathy (TME) and chronic wasting disease (CWD) agents) might have zoonotic potential.

snip...


http://www.efsa.europa.eu/en/efsajournal/pub/e991.htm?emt=1





http://www.efsa.europa.eu/en/efsajournal/doc/e991.pdf





see follow-up here about North America BSE Mad Cow TSE prion risk factors, and the ever emerging strains of Transmissible Spongiform Encephalopathy in many species here in the USA, including humans ;


http://transmissiblespongiformencephalopathy.blogspot.com/2011/10/efsa-journal-2011-european-response-to.html





Thursday, August 12, 2010

Seven main threats for the future linked to prions

First threat

The TSE road map defining the evolution of European policy for protection against prion diseases is based on a certain numbers of hypotheses some of which may turn out to be erroneous. In particular, a form of BSE (called atypical Bovine Spongiform Encephalopathy), recently identified by systematic testing in aged cattle without clinical signs, may be the origin of classical BSE and thus potentially constitute a reservoir, which may be impossible to eradicate if a sporadic origin is confirmed.

***Also, a link is suspected between atypical BSE and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases constitute an unforeseen first threat that could sharply modify the European approach to prion diseases.

Second threat

snip...


http://www.neuroprion.org/en/np-neuroprion.html







Saturday, June 25, 2011

Transmissibility of BSE-L and Cattle-Adapted TME Prion Strain to Cynomolgus Macaque

"BSE-L in North America may have existed for decades"


http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/transmissibility-of-bse-l-and-cattle.html





Over the next 8-10 weeks, approximately 40% of all the adult mink on the farm died from TME.

snip...

The rancher was a ''dead stock'' feeder using mostly (>95%) downer or dead dairy cattle...


http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf





Sunday, February 5, 2012

February 2012 Update on Feed Enforcement Activities to Limit the Spread of BSE

http://transmissiblespongiformencephalopathy.blogspot.com/2012/02/february-2012-update-on-feed.html





Saturday, March 5, 2011

MAD COW ATYPICAL CJD PRION TSE CASES WITH CLASSIFICATIONS PENDING ON THE RISE IN NORTH AMERICA

http://transmissiblespongiformencephalopathy.blogspot.com/2011/03/mad-cow-atypical-cjd-prion-tse-cases.html





Sunday, February 12, 2012

National Prion Disease Pathology Surveillance Center Cases Examined1 (August 19, 2011) including Texas

http://transmissiblespongiformencephalopathy.blogspot.com/2012/02/national-prion-disease-pathology.html





Friday, March 09, 2012

Experimental H-type and L-type bovine spongiform encephalopathy in cattle: observation of two clinical syndromes and diagnostic challenges

Research article

http://bse-atypical.blogspot.com/2012/03/experimental-h-type-and-l-type-bovine.html





USDA OIE ON HOW TO TRADE MAD COW DISEASE GLOBALLY $$$


Sunday, March 11, 2012

APHIS Proposes New Bovine Spongiform Encephalopathy Import Regulations in Line with International Animal Health Standards Proposal Aims to Ensure Health of the U.S. Beef Herd, Assist in Negotiations

http://transmissiblespongiformencephalopathy.blogspot.com/2012/03/aphis-proposes-new-bovine-spongiform.html






Saturday, February 14, 2009

A case-control study of sporadic Creutzfeldt-Jakob disease in Switzerland: analysis of potential risk factors with regard to an increased CJD incidence in the years 2001–2004


http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2637857&blobtype=pdf






>>>The rise in annual mortality rate from the years before 2000 to the period 2001– 2004, however, was statistically significant, and therefore, chance must be considered a less likely explanation.<<<




SEE FULL TEXT AND MORE HERE ;


http://creutzfeldt-jakob-disease.blogspot.com/2009/02/case-control-study-of-sporadic.html





Saturday, March 5, 2011

MAD COW ATYPICAL CJD PRION TSE CASES WITH CLASSIFICATIONS PENDING ON THE RISE IN NORTH AMERICA

http://transmissiblespongiformencephalopathy.blogspot.com/2011/03/mad-cow-atypical-cjd-prion-tse-cases.html



Sunday, February 12, 2012

National Prion Disease Pathology Surveillance Center Cases Examined1 (August 19, 2011) including Texas

http://transmissiblespongiformencephalopathy.blogspot.com/2012/02/national-prion-disease-pathology.html




Tuesday, February 28, 2012

The 27th Colloque Médecine et Recherche of the Fondation Ipsen in the Alzheimer Disease series: “Proteopathic Seeds and Neurodegenerative Diseases”

Press release

http://betaamyloidcjd.blogspot.com/2012/02/27th-colloque-medecine-et-recherche-of.html





TSS

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