Terry S. Singeltary Sr. Publications TSE prion disease
for my files...tss
Diagnosis and Reporting of Creutzfeldt-Jakob Disease
Singeltary, Sr et al. JAMA.2001; 285: 733-734. Vol. 285 No. 6, February 14,
2001 JAMA
Diagnosis and Reporting of Creutzfeldt-Jakob Disease
To the Editor: In their Research Letter, Dr Gibbons and colleagues1
reported that the annual US death rate due to Creutzfeldt-Jakob disease (CJD)
has been stable since 1985. These estimates, however, are based only on reported
cases, and do not include misdiagnosed or preclinical cases. It seems to me that
misdiagnosis alone would drastically change these figures. An unknown number of
persons with a diagnosis of Alzheimer disease in fact may have CJD, although
only a small number of these patients receive the postmortem examination
necessary to make this diagnosis. Furthermore, only a few states have made CJD
reportable. Human and animal transmissible spongiform encephalopathies should be
reportable nationwide and internationally.
Terry S. Singeltary, Sr Bacliff, Tex
1. Gibbons RV, Holman RC, Belay ED, Schonberger LB. Creutzfeldt-Jakob
disease in the United States: 1979-1998. JAMA. 2000;284:2322-2323.
26 March 2003
Terry S. Singeltary, retired (medically) CJD WATCH
I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to comment
on the CDC's attempts to monitor the occurrence of emerging forms of CJD.
Asante, Collinge et al [1] have reported that BSE transmission to the
129-methionine genotype can lead to an alternate phenotype that is
indistinguishable from type 2 PrPSc, the commonest sporadic CJD. However, CJD
and all human TSEs are not reportable nationally. CJD and all human TSEs must be
made reportable in every state and internationally. I hope that the CDC does not
continue to expect us to still believe that the 85%+ of all CJD cases which are
sporadic are all spontaneous, without route/source. We have many TSEs in the USA
in both animal and man. CWD in deer/elk is spreading rapidly and CWD does
transmit to mink, ferret, cattle, and squirrel monkey by intracerebral
inoculation. With the known incubation periods in other TSEs, oral transmission
studies of CWD may take much longer. Every victim/family of CJD/TSEs should be
asked about route and source of this agent. To prolong this will only spread the
agent and needlessly expose others. In light of the findings of Asante and
Collinge et al, there should be drastic measures to safeguard the medical and
surgical arena from sporadic CJDs and all human TSEs. I only ponder how many
sporadic CJDs in the USA are type 2 PrPSc?
2 January 2000
British Medical Journal
U.S. Scientist should be concerned with a CJD epidemic in the U.S., as
well
15 November 1999
British Medical Journal
vCJD in the USA * BSE in U.S.
The Lancet Infectious Diseases, Volume 3, Issue 8, Page 463, August 2003
doi:10.1016/S1473-3099(03)00715-1Cite or Link Using DOI
Tracking spongiform encephalopathies in North America
Original
Xavier Bosch
“My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost my
mom to hvCJD (Heidenhain variant CJD) and have been searching for answers ever
since. What I have found is that we have not been told the truth. CWD in deer
and elk is a small portion of a much bigger problem.” 49-year—old Singeltary is
one of a number of people who have remained largely unsatisfied after being told
that a close relative died from a rapidly progressive dementia compatible with
spontaneous Creutzfeldt—Jakob ...
Suspect symptoms
What if you can catch old-fashioned CJD by eating meat from a sheep
infected with scrapie?
28 Mar 01 Most doctors believe that sCJD is caused by a prion protein
deforming by chance into a killer. But Singeltary thinks otherwise. He is one of
a number of campaigners who say that some sCJD, like the variant CJD related to
BSE, is caused by eating meat from infected animals. Their suspicions have
focused on sheep carrying scrapie, a BSE-like disease that is widespread in
flocks across Europe and North America.
Now scientists in France have stumbled across new evidence that adds weight
to the campaigners' fears. To their complete surprise, the researchers found
that one strain of scrapie causes the same brain damage in mice as sCJD.
"This means we cannot rule out that at least some sCJD may be caused by
some strains of scrapie," says team member Jean-Philippe Deslys of the French
Atomic Energy Commission's medical research laboratory in Fontenay-aux-Roses,
south-west of Paris. Hans Kretschmar of the University of Göttingen, who
coordinates CJD surveillance in Germany, is so concerned by the findings that he
now wants to trawl back through past sCJD cases to see if any might have been
caused by eating infected mutton or lamb...
Tuesday, December 16, 2014
Evidence for zoonotic potential of ovine scrapie prions
Scrapie from sheep could infect humans with 'mad cow disease', study finds
The Pathological Protein:
Mad Cow, Chronic Wasting, and Other Deadly Prion Diseases
Philip Yam
''Answering critics like Terry Singeltary, who feels that the US
undercounts CJD, Schonberger _conceded_ that the current surveillance system has
errors but stated that most of the errors will be confined to the older
population''....end
snip...
His combative, blunt, opinion- ated style sometimes borders on obsessive
ranting that earns praise from some officials and researchers but infuriates
others especially when he repeats his conviction that "the government has lied
to us, the feed industry has lied to us all over a buck." As evidence,
Singeltary cites the USDA's testing approach, which targets downer cows and
examined 19,900 of them in 2002. To him, the USDA should test 1 mil- lion
cattle, because the incidence of BSE may be as low as one in a mil- lion, as it
was in some European countries. That the U.S. does not, he thinks, is a sign
that the government is really not interested in finding mad cows because of
fears of an economic disaster.
Singeltary got into the field of transmissible spongiform encepha- lopathy
in 1997, just after his mother died of sporadic CJD. She had an especially
aggressive version the Heidenhain variant that first causes the patient to go
blind and then to deteriorate rapidly She died just ten weeks after her symptoms
began. Singeltary, who said he had watched his grandparents die of cancer,
considered her death by CJD to be much, much worse: "It's something you never
forget." Her uncon- trollable muscle twitching became so bad "that it took three
of us to hold her one time," Singeltary recalled. "She did everything but
levitate in bed and spin her head."
14th ICID International Scientific Exchange Brochure -
Final Abstract Number: ISE.114
Session: International Scientific Exchange
Transmissible Spongiform encephalopathy (TSE) animal and human TSE in North
America update October 2009
T. Singeltary
Bacliff, TX, USA
Background:
An update on atypical BSE and other TSE in North America. Please remember,
the typical U.K. c-BSE, the atypical l-BSE (BASE), and h-BSE have all been
documented in North America, along with the typical scrapie's, and atypical
Nor-98 Scrapie, and to date, 2 different strains of CWD, and also TME. All these
TSE in different species have been rendered and fed to food producing animals
for humans and animals in North America (TSE in cats and dogs ?), and that the
trading of these TSEs via animals and products via the USA and Canada has been
immense over the years, decades.
Methods:
12 years independent research of available data
Results:
I propose that the current diagnostic criteria for human TSEs only enhances
and helps the spreading of human TSE from the continued belief of the UKBSEnvCJD
only theory in 2009. With all the science to date refuting it, to continue to
validate this old myth, will only spread this TSE agent through a multitude of
potential routes and sources i.e. consumption, medical i.e., surgical, blood,
dental, endoscopy, optical, nutritional supplements, cosmetics etc.
Conclusion:
I would like to submit a review of past CJD surveillance in the USA, and
the urgent need to make all human TSE in the USA a reportable disease, in every
state, of every age group, and to make this mandatory immediately without
further delay. The ramifications of not doing so will only allow this agent to
spread further in the medical, dental, surgical arena's. Restricting the
reporting of CJD and or any human TSE is NOT scientific. Iatrogenic CJD knows NO
age group, TSE knows no boundaries. I propose as with Aguzzi, Asante, Collinge,
Caughey, Deslys, Dormont, Gibbs, Gajdusek, Ironside, Manuelidis, Marsh, et al
and many more, that the world of TSE Transmissible Spongiform Encephalopathy is
far from an exact science, but there is enough proven science to date that this
myth should be put to rest once and for all, and that we move forward with a new
classification for human and animal TSE that would properly identify the
infected species, the source species, and then the route.
re-Self-Propagative Replication of Ab Oligomers Suggests Potential
Transmissibility in Alzheimer Disease
Received July 24, 2014; Accepted September 16, 2014; Published November 3,
2014
Singeltary comment ;
RE: re-Human Prion Diseases in the United States
part 2 flounder replied to flounder on 02 Jan 2010 at 21:26 GMT
No competing interests declared.
No competing interests declared.
see full text ;
*** PLOS Singeltary reply ;
Molecular, Biochemical and Genetic Characteristics of BSE in Canada Singeltary reply ;
http://www.plosone.org/annotation/listThread.action;jsessionid=635CE9094E0EA15D5362B7D7B809448C?root=7143
ruminant feed ban for cervids in the United States ?
Singeltary T. S.
31 Jan 2015 at 20:14 GMT
"Löcher wie in einem Schweizer Käse" hat auch Terry Singeltary im Regelwerk
der FDA ausgemacht. Der Texaner kam auf einem tragischen Umweg zu dem Thema:
Nachdem seine Mutter 1997 binnen weniger Wochen an der
Creutzfeldt-Jakob-Krankheit gestorben war, versuchte er, die Ursachen der
Infektion aufzuspüren. Er klagte auf die Herausgabe von Regierungsdokumenten und
arbeitete sich durch Fachliteratur; heute ist er überzeugt, dass seine Mutter
durch die stetige Einnahme von angeblich kräftigenden Mitteln erkrankte, in
denen - völlig legal - Anteile aus Rinderprodukten enthalten sind.
Von der Fachwelt wurde Singeltary lange als versponnener Außenseiter
belächelt. Doch mittlerweile sorgen sich auch Experten, dass ausgerechnet diese
verschreibungsfreien Wundercocktails zur Stärkung von Intelligenz, Immunsystem
oder Libido von den Importbeschränkungen ausgenommen sind. Dabei enthalten die
Pillen und Ampullen, die in Supermärkten verkauft werden, exotische Mixturen aus
Rinderaugen; dazu Extrakte von Hypophyse oder Kälberföten, Prostata, Lymphknoten
und gefriergetrocknetem Schweinemagen. In die USA hereingelassen werden auch
Blut, Fett, Gelatine und Samen. Diese Stoffe tauchen noch immer in US-Produkten
auf, inklusive Medizin und Kosmetika. Selbst in Impfstoffen waren möglicherweise
gefährliche Rinderprodukte enthalten. Zwar fordert die FDA schon seit acht
Jahren die US-Pharmaindustrie auf, keine Stoffe aus Ländern zu benutzen, in
denen die Gefahr einer BSE-Infizierung besteht. Aber erst kürzlich
verpflichteten sich fünf Unternehmen, darunter Branchenführer wie
GlaxoSmithKline, Aventis und American Home Products, ihre Seren nur noch aus
unverdächtigem Material herzustellen.
"Its as full of holes as Swiss Cheese" says Terry Singeltary of the FDA
regulations. ...
New York Times Magazine The Case of the Cherry Hill Cluster By D.T.
MAX
Published: March 28, 2004
snip...
Skarbek did not know how to surmount this objection. But she was a
go-getter. She wasn't about to give up on her cluster so easily. Fortunately,
she was in contact with Terry Singeltary. She had seen his name quoted often on
the Web in articles on C.J.D. and mad cow. Singeltary lost his mother to an
extremely rare strain of sporadic C.J.D. in 1997. Soon after, he learned that a
year earlier to the day, the mother of his next-door neighbor died of the
disease. Since that time, he has become convinced that these sporadic cases are
not sporadic at all, that mad cow is now a disease of humans in America. He said
he believes that his mother was accidentally infected during surgery and the
mother of his neighbor from taking nutritional supplements made from high-risk
bovine tissue, which he calls ''mad cow in a pill.''
Singeltary has a sloping face and slicked-back hair. He is nearsighted,
with small blue eyes. He looks like Lewis Carroll's White Rabbit. From his
living room in Bacliff, Tex., he dominates the listservs and message boards of
an online debate over sporadic C.J.D. -- the scientists who say it exists; the
heartbroken family members who doubt it. Early, deep in his grief, he would sign
his e-mail messages to scientists, ''I am the madson of a deadmom who died of
madcow.'' Singeltary turned out to be helpful for Skarbek. He pointed her to a
paper that was published in 2002 in the journal of the European Molecular
Biology Organization by John Collinge, the premier prion researcher in England.
Collinge argued that experiments conducted in mice suggest that infections with
mad cow can sometimes look like sporadic C.J.D. Collinge accepted the
implications: he recommended that ''serious consideration should be given'' to
the idea that some of the more recent sporadic C.J.D. cases in Europe were in
fact related to mad cow disease.
2014
***Moreover, L-BSE has been transmitted more easily to transgenic mice
overexpressing a human PrP [13,14] or to primates [15,16] than C-BSE.
***It has been suggested that some sporadic CJD subtypes in humans may
result from an exposure to the L-BSE agent.
*** Lending support to this hypothesis, pathological and biochemical
similarities have been observed between L-BSE and an sCJD subtype (MV genotype
at codon 129 of PRNP) [17], and between L-BSE infected non-human primate and
another sCJD subtype (MM genotype) [15].
snip...
BSE prions propagate as either variant CJD-like or sporadic CJD-like prion
strains in transgenic mice expressing human prion protein
*** Surprisingly, however, BSE transmission to these transgenic mice, in
addition to producing a vCJD-like phenotype, can also result in a distinct
molecular phenotype that is indistinguishable from that of sporadic CJD with
PrPSc type 2.
These data suggest that more than one BSEderived prion strain might infect
humans;
***it is therefore possible that some patients with a phenotype consistent
with sporadic CJD may have a disease arising from BSE exposure.
snip...
These studies further strengthen the evidence that vCJD is caused by a
BSE-like prion strain.
Also, remarkably, the key neuropathological hallmark of vCJD, the presence
of abundant florid PrP plaques, can be recapitulated on BSE or vCJD transmission
to these mice.
***However, the most surprising aspect of the studies was the finding that
an alternate pattern of disease can be induced in 129MM Tg35 mice from primary
transmission of BSE, with a molecular phenotype indistinguishable from that of a
subtype of sporadic CJD. This finding has important potential implications as it
raises the possibility that some humans infected with BSE prions may develop a
clinical disease indistinguishable from classical CJD associated with type 2
PrPSc. This is, in our experience, the commonest molecular sub-type of sporadic
CJD. In this regard, it is of interest that the reported incidence of sporadic
CJD has risen in the UK since the 1970s (Cousens et al., 1997)...
To date the OIE/WAHO assumes that the human and animal health standards set
out in the BSE chapter for classical BSE (C-Type) applies to all forms of BSE
which include the H-type and L-type atypical forms. This assumption is
scientifically not completely justified and accumulating evidence suggests that
this may in fact not be the case. Molecular characterization and the spatial
distribution pattern of histopathologic lesions and immunohistochemistry (IHC)
signals are used to identify and characterize atypical BSE. Both the L-type and
H-type atypical cases display significant differences in the conformation and
spatial accumulation of the disease associated prion protein (PrPSc) in brains
of afflicted cattle. Transmission studies in bovine transgenic and wild type
mouse models support that the atypical BSE types might be unique strains because
they have different incubation times and lesion profiles when compared to C-type
BSE. When L-type BSE was inoculated into ovine transgenic mice and Syrian
hamster the resulting molecular fingerprint had changed, either in the first or
a subsequent passage, from L-type into C-type BSE.
***In addition, non-human primates are specifically susceptible for
atypical BSE as demonstrated by an approximately 50% shortened incubation time
for L-type BSE as compared to C-type. Considering the current scientific
information available, it cannot be assumed that these different BSE types pose
the same human health risks as C-type BSE or that these risks are mitigated by
the same protective measures.
-------- Original Message --------
Subject: re-BSE prions propagate as either variant CJD-like or sporadic CJD
Date: Thu, 28 Nov 2002 10:23:43 -0000
From: "Asante, Emmanuel A" e.asante@ic.ac.uk
To: "'flounder@wt.net'" flounder@wt.net
Dear Terry,
I have been asked by Professor Collinge to respond to your request. I am a
Senior Scientist in the MRC Prion Unit and the lead author on the paper. I have
attached a pdf copy of the paper for your attention.
Thank you for your interest in the paper.
In respect of your first question, the simple answer is, ***yes. As you
will find in the paper, we have managed to associate the alternate phenotype to
type 2 PrPSc, the commonest sporadic CJD. It is too early to be able to claim
any further sub-classification in respect of Heidenhain variant CJD or Vicky
Rimmer's version. It will take further studies, which are on-going, to establish
if there are sub-types to our initial finding which we are now reporting. The
main point of the paper is that, as well as leading to the expected new variant
CJD phenotype, BSE transmission to the 129-methionine genotype can lead to an
alternate phenotype which is indistinguishable from type 2 PrPSc.
I hope reading the paper will enlighten you more on the subject. If I can
be of any further assistance please to not hesitate to ask. Best wishes.
Emmanuel Asante
<>
____________________________________
Dr. Emmanuel A Asante MRC Prion Unit & Neurogenetics Dept. Imperial
College School of Medicine (St. Mary's) Norfolk Place, LONDON W2 1PG Tel: +44
(0)20 7594 3794 Fax: +44 (0)20 7706 3272 email: e.asante@ic.ac.uk (until
9/12/02) New e-mail: e.asante@prion.ucl.ac.uk (active from now)
____________________________________ END
Aug. 5, 2001, 12:25AM
Mad cow disease: Could it be here?
Man's stubborn crusade attracts experts' notice
By CAROL CHRISTIAN Copyright 2001 Houston Chronicle
Like Paul Revere with e-mail, Terry Singeltary Sr. is on a mission to sound
an alarm: Beware of mad cow disease.
As is true of many crusaders, however, his pleas often fall on deaf ears.
Health officials here and abroad insist that bovine spongiform encephalopathy --
popularly known as mad cow disease, a fatal brain disorder that can make cows
shake uncontrollably -- has been kept out of this country through surveillance
of the cattle industry.
But since his mother's death in December 1997, the Galveston County man has
been obsessed with possible connections between her deadly brain disorder,
sporadic Creutzfeldt-Jakob Disease, and mad cow disease.
And after much persistence on his part, people are taking notice of this
former machinist and high school dropout who jokes that he has a Ph.D. -- a Pool
Hall Degree.
"They called me Chicken Little for four years," he said. "Now they're
calling back, asking for more information."
For the past year he has been U.S. co-coordinator of an international
monitoring group called CJD Watch. He regularly gets e-mail from scientists and
journalists around the world.
Debora MacKenzie, a reporter for the British magazine New Scientist,
described Singeltary, 47, as a "dogged unearther and tabulator of government
documents." Singeltary monitors "every word written about CJD/BSE," said Anita
Manning of USA Today, also by e-mail.
"He's passionate, opinionated and not always tactful, although I like him
because he's such a character and he is so transparent," Manning said. "He is
what he appears to be."
Science and environment writer Jonathan Leake of the Sunday Times in London
said Singeltary has helped him track down families of people with CJD along with
academic research papers.
"I strongly suspect he is right in thinking the USA has had BSE cases,"
Leake said by e-mail.
"The American government is making the same mistake as the British in
putting the short-term commercial interests of its farmers before health
considerations," he added.
"It should start formal and widespread testing of cattle plus compulsory
autopsies for all human CJD victims at the state's expense. If there is BSE,
then leaving it to spread will kill people -- and that would eventually destroy
the industry, too."
Texas Department of Health epidemiologist Julie Rawlings said Singeltary's
careful monitoring of the disease had proven useful.
"Terry has been helpful in providing contact information regarding suspect
CJD cases so that the Health Department can initiate case investigations and
learn more about CJD in Texas," she said.
Noting that the department cannot release records on individual patients,
she added, "I think we learn more from him than he does from us."
Mad cow disease surfaced in England in 1986 and quickly became an epidemic.
It since has been reported in 15 European countries, most recently Greece on
July 2, and the Czech Republic on June 14. Two German-born cows tested positive
for BSE in November.
Singeltary said he became convinced that BSE is here as he watched his
mother, Barbara Poulter of Crystal Beach, dying of sporadic Creutzfeldt-Jakob
Disease. The rare, fatal brain disease is sometimes accompanied by severe
jerking.
"She would jerk so bad at times, it would take three of us to hold her
down," Singeltary said. "They can call it whatever they want, but I know what I
saw, and what she went through. `Sporadic' simply means they don't know."
Poulter, a retired telephone-company field worker, had a form of sporadic
CJD -- Haidenhain variant -- that is even less common than the typical sporadic
case. One of its first symptoms is loss of vision.
She started seeing brown spots in September 1997 and was virtually blind
within two weeks. By the eighth week of the illness Poulter was bedridden, and
in the 10th week she died. Before that she had been in good health.
In many countries and most U.S. states, physicians are not required to
report CJD cases to health officials. Texas made the disease reportable in 1998.
Through 2000, there were 17 probable or confirmed cases, according to the Texas
Department of Health.
In mid-June, a case of sporadic CJD was confirmed through brain biopsy at
Christus Spohn Hospital Shoreline in Corpus Christi, said Jane Bakos, hospital
vice president. The patient has since died, the hospital reported.
CJD and mad cow disease leave their victims' brains full of holes like a
sponge.
Although not contagious, the illnesses are thought to be transmissible
through prions, or nearly indestructible abnormal proteins.
Because the prion protein is not killed by standard sterilization, sporadic
CJD can be spread by contaminated surgical instruments.
In March 1996, the British government announced the discovery of a new
variant of CJD, most likely explained by exposure to bovine spongiform
encephalopathy.
Through June, 101 cases of new-variant CJD have been reported in the United
Kingdom, three in France and one in Ireland. In contrast to sporadic CJD, the
new variant usually affects younger patients and lasts longer.
No cases of new-variant CJD or BSE have been reported in the United States.
No relationship has been shown between sporadic CJD and mad cow disease.
There is no indication that new-variant CJD can be spread through blood
transfusions, but a U.S. Food and Drug Administration advisory committee voted
in June to broaden the categories for excluding potential donors. The
recommendations have not yet been approved by the FDA.
The American Red Cross has announced that on Sept. 17 it will begin
rejecting potential blood donors who, since 1980, have spent at least three
months in the United Kingdom or at least six months in any European country or
combination of countries. Those who have received a blood transfusion in Britain
since 1980 also will be rejected.
The primary collector of local blood donations is the Gulf Coast Regional
Blood Center, which will follow the FDA's guidelines, said Bill Teague,
president and chief executive officer.
Singeltary said it's naive to think that U.S. prevention efforts have kept
mad cow and new-variant CJD out of the United States.
"They haven't found it," he said, "because they haven't looked."
For one thing, he said, too few cows are tested for the disease. In the
first six months of this year, the European Union tested more than 3.2 million
cows, David Byrne of the European Commission said in a speech last month.
By contrast, it took the U.S. Department of Agriculture nearly 10 years to
analyze about 13,000 cow brains, according to the department's Web site.
With more than 68 million cattle slaughtered since 1990 in the United
States, according to the USDA, checking about 13,000 falls far short, Singeltary
said.
Though not a scholar, Singeltary has collected voluminous material on mad
cow and CJD. Disabled from a neck injury, Singeltary never used a computer until
1998.
He now spends hours each day on the Internet while his wife, Bonnie
Singeltary, runs a flower shop in their home in Bacliff, in north Galveston
County.
His challenge to the CJD/BSE establishment is courageous and refreshing,
said Dr. Lynette Dumble, former visiting professor of surgery at University of
Texas Medical School at Houston and a former senior research fellow in the
history and philosophy of science at the University of Melbourne in
Australia.
"I certainly have no problem with Terry's ideas on BSE/CJD," said Dumble,
who coordinates the Global Sisterhood Network, a computer service that posts
media reports on developments affecting women. "His research skills are
excellent, and he is abreast of each and every development in the field."
Among Singeltary's worries now, he said, are widespread violations of an
August 1997 ban on feeding animal products to U.S. cattle. The FDA reported in
January that hundreds of feed manufacturers were not complying with regulations
designed to keep BSE out of this country.
(That same month, a Purina Mills feedlot near San Antonio told the FDA that
a "very low level" of cow parts had been found in cattle feed. The company
voluntarily removed 1,222 animals who had been fed the prohibited
materials.)
He obtained copies of FDA letters to various feed mills that had been found
in violation of the regulations and immediately sent them by e-mail to hundreds
of people around the world.
Singeltary might not be so zealous in getting the word out if he weren't
convinced that someone is covering up the truth.
"They used to say BSE would never transmit to humans," he said, "and it
has. They lied about the feed ban being in place.
"I've lost faith in the whole process. I've discovered too many things."
Tuesday, March 16, 2010
COMMONWEALTH OF AUSTRALIA Hansard Import restrictions on beef FRIDAY, 5
FEBRUARY 2010 AUSTRALIA
COMMONWEALTH OF AUSTRALIA
Proof Committee Hansard
RRA&T 2 Senate Friday, 5 February 2010
RURAL AND REGIONAL AFFAIRS AND TRANSPORT
[9.03 am]
BELLINGER, Mr Brad, Chairman, Australian Beef Association CARTER, Mr John
Edward, Director, Australian Beef Association CHAIR—Welcome. Would you like to
make an opening statement? Mr Bellinger—Thank you. The ABA stands by its
submission, which we made on 14 December last year, that the decision made by
the government to allow the importation of beef from BSE affected countries is
politically based, not science based. During this hearing we will bring forward
compelling new evidence to back up this statement. When I returned to my
property after the December hearing I received a note from an American citizen.
I will read a small excerpt from the mail he sent me in order to reinforce the
dangers of allowing the importation of beef from BSE affected countries. I have
done a number of press releases on this topic, and this fellow has obviously
picked my details up from the internet. His name is Terry Singeltary and he is
from Bacliff, Texas. He states, and rightfully so: You should be worried. Please
let me explain. I’ve kept up with the mad cow saga for 12 years today, on
December 14th 1997, some four months post voluntary and partial mad cow feed ban
in the USA, I lost my mother to the Heinemann variant Creutzfeldt-Jakob disease
(CJD). I know this is just another phenotype of the infamous sporadic CJDs. Here
in the USA, when USA sheep scrapie was transmitted to USA bovine, the agent was
not UK BSE—it was a different strain. So why then would human TSE from USA
cattle look like UK CJD from UK BSE? It would not. So this accentuates that the
science is inconclusive still on this devastating disease. He goes on to state:
snip...see full text 110 pages ;
for those interested, please see much more here ;
This document provides itemized replies to the public comments received on
the 2005 updated Harvard BSE risk assessment. Please bear the following points
in mind:
Owens, Julie From: Terry S. Singeltary Sr. [flounder9@verizon.net]
Sent: Monday, July 24, 2006 1:09 PM To: FSIS RegulationsComments
Subject: [Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine
Spongiform Encephalopathy (BSE) Page 1 of 98 8/3/2006
Greetings FSIS, I would kindly like to comment on the following ;
Nature | Editorial
Needless conflict Nature 485, 279–280 (17 May 2012) doi:10.1038/485279b
Published online 16 May 2012
Tuesday, December 2, 2014
UK EXPORTS OF MBM TO WORLD Bovine Spongiform Encephalopathy BSE TSE Prion
aka Mad Cow Disease
USA, NORTH AMERICA, MBM (or any potential TSE prion disease) EXPORTS TO THE
WORLD (?) [protected by the BSE MRR policy] $$$
*** Qualitative Analysis of BSE Risk Factors in the United States
February 13, 2000 at 3:37 pm PST (BSE red book)
Tuesday, July 14, 2009 U.S.
*** Emergency Bovine Spongiform Encephalopathy Response Plan Summary and
BSE Red Book
Date: February 14, 2000 at 8:56 am PST
WHERE did we go wrong $$$
Friday, November 22, 2013
Wasting disease is threat to the entire UK deer population CWD TSE PRION
disease in cervids
***SINGELTARY SUBMISSION
The Scottish Parliament’s Rural Affairs, Climate Change and Environment
Committee has been looking into deer management, as you can see from the
following press release,
***and your email has been forwarded to the committee for information:
Sunday, July 21, 2013
Welsh Government and Food Standards Agency Wales Joint Public Consultation
on the Proposed Transmissible Spongiform Encephalopathies (Wales) Regulations
2013
*** Singeltary Submission WG18417
*** The potential impact of prion diseases on human health was greatly
magnified by the recognition that interspecies transfer of BSE to humans by beef
ingestion resulted in vCJD. While changes in animal feed constituents and
slaughter practices appear to have curtailed vCJD, there is concern that CWD of
free-ranging deer and elk in the U.S. might also cross the species barrier.
Thus, consuming venison could be a source of human prion disease. Whether BSE
and CWD represent interspecies scrapie transfer or are newly arisen prion
diseases is unknown. Therefore, the possibility of transmission of prion disease
through other food animals cannot be ruled out. There is evidence that vCJD can
be transmitted through blood transfusion. There is likely a pool of unknown size
of asymptomatic individuals infected with vCJD, and there may be asymptomatic
individuals infected with the CWD equivalent. These circumstances represent a
potential threat to blood, blood products, and plasma supplies.
Friday, December 5, 2014
***SPECIAL ALERT***
The OIE recommends strengthening animal disease surveillance worldwide
OIE BSE TSE PRION AKA MAD COW DISEASE ?
‘’the silence was deafening’’ ...tss
Terry S. Singeltary Sr. on the Creutzfeldt-Jakob Disease Public Health
Crisis *video*
Transmissible Spongiform Encephalopathy TSE Prion Disease North America
2014
Transmissible Spongiform Encephalopathy TSE Prion Disease have now been
discovered in a wide verity of species across North America. typical C-BSE,
atypical L-type BASE BSE, atypical H-type BSE, atypical H-G BSE, of the bovine,
typical and atypical Scrapie strains, in sheep and goats, with atypical Nor-98
Scrapie spreading coast to coast in about 5 years. Chronic Wasting Disease CWD
in cervid is slowly spreading without any stopping it in Canada and the USA and
now has mutated into many different strains. Transmissible Mink Encephalopathy
TME outbreaks. These Transmissible Spongiform Encephalopathy TSE Prion Disease
have been silently mutating and spreading in different species in North America
for decades.
The USDA, FDA, et al have assured us of a robust Triple BSE TSE prion
Firewall, of which we now know without a doubt, that it was nothing but ink on
paper. Since the 1997 mad cow feed ban in the USA, literally tons and tons of
banned mad cow feed has been put out into commerce, never to return, as late as
December of 2013, serious, serious breaches in the FDA mad cow feed ban have
been documented. The 2004 enhanced BSE surveillance program was so flawed, that
one of the top TSE prion Scientist for the CDC, Dr. Paul Brown stated ; Brown,
who is preparing a scientific paper based on the latest two mad cow cases to
estimate the maximum number of infected cows that occurred in the United States,
said he has "absolutely no confidence in USDA tests before one year ago" because
of the agency's reluctance to retest the Texas cow that initially tested
positive.
see ;
The BSE surveillance and testing have also been proven to be flawed, and
the GAO and OIG have both raised serious question as to just how flawed it has
been (see GAO and OIG reports). North America has more documented TSE prion
disease, in different documented species (excluding the Zoo BSE animals in the
EU), then any other place on the Globe. This does not include the very
likelihood that TSE prion disease in the domestic feline and canine have been
exposed to high doses of the TSE prion disease vid pet food. To date, it’s still
legal to include deer from cwd zone into pet food or deer food. Specified Risk
Material i.e. SRM bans still being breach, as recently as just last month.
nvCJD or what they now call vCJD, another case documented in Texas last
month, with very little information being released to the public on about this
case? with still the same line of thought from federal officials, ‘it can’t
happen here’, so another vCJD blamed on travel of a foreign animal disease from
another country, while ignoring all the BSE TSE Prion risk factors we have here
in the USA and Canada, and the time that this victim and others, do spend in the
USA, and exposed to these risk factors, apparently do not count in any way with
regard to risk factor. a flawed process of risk assessment.
sporadic CJD, along with new TSE prion disease in humans, of which the
young are dying, of which long duration of illness from onset of symptoms to
death have been documented, only to have a new name added to the pot of prion
disease i.e. sporadic GSS, sporadic FFI, and or VPSPR. I only ponder how a
familial type disease could be sporadic with no genetic link to any family
member? when the USA is the only documented Country in the world to have
documented two different cases of atypical H-type BSE, with one case being
called atypical H-G BSE with the G meaning Genetic, with new science now showing
that indeed atypical H-type BSE is very possible transmitted to cattle via oral
transmission (Prion2014). sporadic CJD and VPSPR have been rising in Canada,
USA, and the UK, with the same old excuse, better surveillance. You can only use
that excuse for so many years, for so many decades, until one must conclude that
CJD TSE prion cases are rising. a 48% incease in CJD in Canada is not just a
blip or a reason of better surveillance, it is a mathematical rise in numbers.
More and more we are seeing more humans exposed in various circumstance in the
Hospital, Medical, Surgical arenas to the TSE Prion disease, and at the same
time in North America, more and more humans are becoming exposed to the TSE
prion disease via consumption of the TSE prion via deer and elk, cattle, sheep
and goats, and for those that are exposed via or consumption, go on to further
expose many others via the iatrogenic modes of transmission of the TSE prion
disease i.e. friendly fire. I pondered this mode of transmission via the victims
of sporadic FFI, sporadic GSS, could this be a iatrogenic event from someone
sub-clinical with sFFI or sGSS ? what if?
Two decades have passed since Dr. Ironside first confirmed his first ten
nvCJD victims in 1995. Ten years later, 2005, we had Dr. Gambetti and his first
ten i.e. VPSPR in younger victims. now we know that indeed VPSPR is
transmissible. yet all these TSE prion disease and victims in the USA and Canada
are being pawned off as a spontaneous event, yet science has shown, the
spontaneous theory has never been proven in any natural case of TSE prion
disease, and scientist have warned, that they have now linked some sporadic CJD
cases to atypical BSE, to atypical Scrapie, and to CWD, yet we don’t here about
this in the public domain. We must make all human and animal TSE prion disease
reportable in every age group, in ever state and internationally, we must have a
serious re-evaluation and testing of the USA cattle herds, and we must ban
interstate movement of all cervids. Any voluntary effort to do any of this will
fail. Folks, we have let the industry run science far too long with regards to
the TSE prion disease. While the industry and their lobbyist continues to funnel
junk science to our decision policy makers, Rome burns. ...end
REFERENCES
Sunday, June 29, 2014
Transmissible Spongiform Encephalopathy TSE Prion Disease North America
2014
***Also, a link is suspected between atypical BSE and some apparently
sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases
constitute an unforeseen first threat that could sharply modify the European
approach to prion diseases.
Second threat
snip...
cattle (namely L-type Atypical BSE, Classical BSE in sheep, transmissible
mink encephalopathy (TME) and chronic wasting disease (CWD) agents) might have
zoonotic potential.
snip...
2014
***Moreover, L-BSE has been transmitted more easily to transgenic mice
overexpressing a human PrP [13,14] or to primates [15,16] than C-BSE.
***It has been suggested that some sporadic CJD subtypes in humans may
result from an exposure to the L-BSE agent.
*** Lending support to this hypothesis, pathological and biochemical
similarities have been observed between L-BSE and an sCJD subtype (MV genotype
at codon 129 of PRNP) [17], and between L-BSE infected non-human primate and
another sCJD subtype (MM genotype) [15].
snip...
U.S.A. 50 STATE BSE MAD COW CONFERENCE CALL Jan. 9, 2001
Sunday, November 23, 2014
Confirmed Variant Creutzfeldt-Jakob Disease (variant CJD) Case in Texas in
June 2014 confirmed as USA case NOT European
The completed investigation did not support the patient's having had
extended travel to European countries, including the United Kingdom, or travel
to Saudi Arabia. The specific overseas country where this patient’s infection
occurred is less clear largely because the investigation did not definitely link
him to a country where other known vCJD cases likely had been infected.
BSE INQUIRY DFAs
Sunday, May 18, 2008
BSE Inquiry DRAFT FACTUAL ACCOUNT DFA
BSE Inquiry DRAFT FACTUAL ACCOUNTS DFA's
Sunday, May 18, 2008
BSE, CJD, and Baby foods (the great debate 1999 to 2005)
Sunday, May 18, 2008
MAD COW DISEASE BSE CJD CHILDREN VACCINES
layperson
just made a promise, never forget, never let them forget...
MOM DOD 12/14/97 confirmed hvCJD Heidenhain Variant Creutzfeldt Jakob
Disease Case Report
snip...
Heidenhain Variant Creutzfeldt Jakob Disease autopsy case report 'MOM'
DIVISION OF NEUROPATHOLOGY University of Texas Medical Branch 114
McCullough Bldg. Galveston, Texas 77555-0785 FAX COVER SHEET DATE: 4-23-98 TO:
Mr. Terry Singeltary @ ------- FROM: Gerald Campbell FAX: (409) 772-5315 PHONE:
(409) 772-2881 Number of Pages (including cover sheet): Message:
*CONFIDENTIALITY NOTICE* This document accompanying this transmission contains
confidential information belonging to the sender that is legally privileged.
This information is intended only for the use of the individual or entry names
above. If you are not the intended recipient, you are hereby notified that any
disclosure, copying distribution, or the taking of any action in reliances on
the contents of this telefaxed information is strictly prohibited. If you
received this telefax in error, please notify us by telephone immediately to
arrange for return of the original documents.
--------------------------
Patient Account: 90000014-518 Med. Rec. No.: (0160)118511Q
Patient Name: POULTER, BARBARA
Age: 63
YRS DOB: 10/17/34
Sex: F
Admitting Race: C
Attending Dr.: Date / Time Admitted : 12/14/97 1228
Copies to: UTMB University of Texas Medical Branch Galveston, Texas
77555-0543 (409) 772-1238 Fax (409) 772-5683 Pathology Report
FINAL AUTOPSY DIAGNOSIS
Autopsy' Office (409)772-2858 Autopsy NO.: AU-97-00435 AUTOPSY INFORMATION:
Occupation: Unknown Birthplace: Unknown Residence: Crystal Beach Date/Time
of Death: 12/14/97 13:30 Date/Time of Autopsy: 12/15/97 15:00
Pathologist/Resident: Pencil/Fernandez Service: Private Restriction:
Brain only FINAL AUTOPSY DIAGNOSIS I. Brain: Creutzfeldt-Jakob disease,
Heidenhain variant.
snip...see full text ;
TSS
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