Scrapie TSE Prion is zoonotic Transmission data also revealed that several
scrapie prions propagate in HuPrP-Tg mice with efficiency comparable to that of
cattle BSE. While the efficiency of transmission at primary passage was low,
subsequent passages resulted in a highly virulent prion disease in both Met129
and Val129 mice. Transmission of the different scrapie isolates in these mice
leads to the emergence of prion strain phenotypes that showed similar
characteristics to those displayed by MM1 or VV2 sCJD prion. These results
demonstrate that scrapie prions have a zoonotic potential and raise new
questions about the possible link between animal and human prions.
Zoonotic Potential of CWD Prions: An Update
Ignazio Cali1, Liuting Qing1, Jue Yuan1, Shenghai Huang2, Diane Kofskey1,3,
Nicholas Maurer1, Debbie McKenzie4, Jiri Safar1,3,5, Wenquan Zou1,3,5,6,
Pierluigi Gambetti1, Qingzhong Kong1,5,6
1Department of Pathology, 3National Prion Disease Pathology Surveillance
Center, 5Department of Neurology, 6National Center for Regenerative Medicine,
Case Western Reserve University, Cleveland, OH 44106, USA.
4Department of Biological Sciences and Center for Prions and Protein
Folding Diseases, University of Alberta, Edmonton, Alberta, Canada,
2Encore Health Resources, 1331 Lamar St, Houston, TX 77010
Chronic wasting disease (CWD) is a widespread and highly transmissible
prion disease in free-ranging and captive cervid species in North America. The
zoonotic potential of CWD prions is a serious public health concern, but the
susceptibility of human CNS and peripheral organs to CWD prions remains largely
unresolved. We reported earlier that peripheral and CNS infections were detected
in transgenic mice expressing human PrP129M or PrP129V. Here we will present an
update on this project, including evidence for strain dependence and influence
of cervid PrP polymorphisms on CWD zoonosis as well as the characteristics of
experimental human CWD prions.
PRION 2016 TOKYO
In Conjunction with Asia Pacific Prion Symposium 2016
PRION 2016 Tokyo
Prion 2016
*** These results would seem to suggest that CWD does indeed have zoonotic
potential, at least as judged by the compatibility of CWD prions and their human
PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests
that if zoonotic CWD occurred, it would most likely effect those of the PRNP
codon 129-MM genotype and that the PrPres type would be similar to that found in
the most common subtype of sCJD (MM1).***
Saturday, April 23, 2016
*** SCRAPIE WS-01: Prion diseases in animals and zoonotic potential 2016
***
Prion. 10:S15-S21. 2016 ISSN: 1933-6896 printl 1933-690X online
Monday, May 02, 2016
*** Zoonotic Potential of CWD Prions: An Update Prion 2016 Tokyo ***
Wednesday, June 29, 2016
NIH awards $11 million to UTHealth researchers to study deadly CWD prion
diseases Claudio Soto, Ph.D.
Public Release: 29-Jun-2016
Friday, July 01, 2016
TEXAS Thirteen new cases of chronic wasting disease (CWD) were confirmed at
a Medina County captive white-tailed deer breeding facility on June 29,
2016
*** How Did CWD Get Way Down In Medina County, Texas?
DISCUSSION Observations of natural outbreaks of scrapie indicated that the
disease spread from flock to flock by the movement of infected, but apparently
normal, sheep which were incubating the disease.
There was no evidence that the disease spread to adjacent flocks in the
absent of such movements or that vectors or other host species were involved in
the spread of scrapie to sheep or goats; however, these possibilities should be
kept open...
Tuesday, June 07, 2016
*** Comparison of two US sheep scrapie isolates supports identification as
separate strains ***
Research Project: TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF
TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES
Scrapie-like disorder in a Nyala (Tragelaphus angasi)
IN CONFIDENCE
Spongiform encephalopathy has so far only been recorded in the sheep and
goat, man, mink, and several deer including the mule deer, black tailed deer and
the elk (most, if not all, of the deer incidents occurred in wild life parts in
Wyoming and Colorado). Clinical cases in deer all occurred from 3 1/2 to 5 years
old and usually 60-80% losses occurred over a 4 year period...
The clinical and neuropathological findings in F22 are consistent with the
spongiform encephalopathies of animals and man. The agents causing spongiform
encephalopathy in various species cannot be unequivocally distinguished and some
isolates of human agent cause neurologic disease in goats indistinguishable from
scrapie. The spongiform encephalopathies are invariably fatal once clinical
signs of disease are evident and as very high fatality rates (79% of 67 animals)
are recorded in Mule deer it is important that an awareness of the disease is
maintained at Marwell.
”The occurrence of CWD must be viewed against the contest of the locations
in which it occurred. It was an incidental and unwelcome complication of the
respective wildlife research programmes. Despite it’s subsequent recognition as
a new disease of cervids, therefore justifying direct investigation, no specific
research funding was forthcoming. The USDA veiwed it as a wildlife problem and
consequently not their province!” page 26.
Saturday, May 28, 2016
*** Infection and detection of PrPCWD in soil from CWD infected farm in
Korea Prion 2016 Tokyo ***
Friday, February 05, 2016
Report of the Committee on Wildlife Diseases FY2015 CWD TSE PRION
Detections in Farmed Cervids and Wild
Saturday, April 23, 2016
*** SCRAPIE WS-01: Prion diseases in animals and zoonotic potential 2016
***
Prion. 10:S15-S21. 2016 ISSN: 1933-6896 printl 1933-690X online
Monday, May 02, 2016
*** Zoonotic Potential of CWD Prions: An Update Prion 2016 Tokyo ***
Wednesday, June 29, 2016
NIH awards $11 million to UTHealth researchers to study deadly CWD prion
diseases Claudio Soto, Ph.D.
Public Release: 29-Jun-2016
Terry S. Singeltary Sr. Bacliff, Texas USA 77518 flounder9@verizon.net
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