SUMMARY REPORT CALIFORNIA BOVINE SPONGIFORM ENCEPHALOPATHY CASE
INVESTIGATION JULY 2012
Summary Report BSE 2012
Executive Summary
On April 24, 2012, the U.S. Department of Agriculture (USDA) announced a
fourth case of bovine spongiform encephalopathy (BSE) in the United States. The
index animal was a 10 year 7 month-old Holstein cow from a central California
dairy. The animal was sampled by a renderer contracted to collect samples as
part of USDA’s ongoing BSE surveillance. Results from immunohistochemistry and
Western blot tests at USDA’s National Veterinary Services Laboratories (NVSL)
confirmed the animal positive for atypical BSE.
Two offspring of the index animal were designated as at-risk cattle. One
was traced out-of-State and depopulated with “not detected” BSE test results.
The other offspring was stillborn. The carcass of the index animal (along with
approximately 90 other carcasses being held at the renderer’s transfer station),
were disposed of in a landfill in accordance with all Federal, State and local
regulations. The carcass of the index animal did not enter the human or animal
food chain.
In conjunction with USDA’s investigation, the U.S. Department of Health and
Human Services’ Food and Drug Administration (FDA) and the California Department
of Food and Agriculture (CDFA) conducted an extensive feed investigation. Twelve
feed suppliers were identified to the index premises; one of which was no longer
in business. The remaining 11 were found to be in compliance with FDA and CDFA
regulations and requirements.
SEE FULL INVESTIGATION HERE ;
***Also, a link is suspected between atypical BSE and some apparently
sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases
constitute an unforeseen first threat that could sharply modify the European
approach to prion diseases.
Second threat
snip...
MAD COW USDA ATYPICAL L-TYPE BASE BSE, the rest of the story...
***Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate
Model
***Infectivity in skeletal muscle of BASE-infected cattle
***feedstuffs- It also suggests a similar cause or source for atypical BSE
in these countries.
***Also, a link is suspected between atypical BSE and some apparently
sporadic cases of Creutzfeldt-Jakob disease in humans.
The present study demonstrated successful intraspecies transmission of
H-type BSE to cattle and the distribution and immunolabeling patterns of PrPSc
in the brain of the H-type BSE-challenged cattle. TSE agent virulence can be
minimally defined by oral transmission of different TSE agents (C-type, L-type,
and H-type BSE agents) [59]. Oral transmission studies with H-type BSEinfected
cattle have been initiated and are underway to provide information regarding the
extent of similarity in the immunohistochemical and molecular features before
and after transmission.
In addition, the present data will support risk assessments in some
peripheral tissues derived from cattle affected with H-type BSE.
in the url that follows, I have posted
SRM breaches first, as late as 2011.
then
MAD COW FEED BAN BREACHES AND TONNAGES OF MAD COW FEED IN COMMERCE up until
2007, when they ceased posting them.
then,
MAD COW SURVEILLANCE BREACHES.
Friday, May 18, 2012
Update from APHIS Regarding a Detection of Bovine Spongiform Encephalopathy
(BSE) in the United States Friday May 18, 2012
Wednesday, May 30, 2012
PO-028: Oral transmission of L-type bovine spongiform encephalopathy
(L-BSE) in primate model Microcebus murinus
Monday, June 18, 2012
R-CALF Submits Incomplete Comments Under Protest in Bizarre Rulemaking
“Bovine Spongiform Encephalopathy; Importation of Bovines and Bovine Products”
Monday, July 23, 2012
The National Prion Disease Pathology Surveillance Center July 2012
Wednesday, June 27, 2012
First US BSE Case Since 2006 Underscores Need for Vigilance
Neurology Today 21 June 2012
Tuesday, June 26, 2012
Creutzfeldt Jakob Disease Human TSE report update North America, Canada,
Mexico, and USDA PRION UNIT as of May 18, 2012
type determination pending Creutzfeldt Jakob Disease (tdpCJD), is on the
rise in Canada and the USA
TSS
From: oie-info-web@oie.int Sent: Friday, April 27, 2012 2:47 AM To: OIE
Mailing List Subject: USA 27-04-12 OIE Alert - Alerta - Alerte - Bovine
spongiform encephalopathy - Encéphalopathie spongiforme bovine - Encefalopatía
espongiforme bovina
English PDF reports Français Rapports PDF Español informes PDF
Bovine spongiform encephalopathy, United States of America
Information received on 26/04/2012 from Dr John Clifford, Deputy
Administrator, Animal and Plant Health Inspection Service, United States
Department of Agriculture, Washington, United States of America
Summary
Report type Immediate notification Start date 19/04/2012 Date of first
confirmation of the event 23/04/2012 Report date 26/04/2012 Date submitted to
OIE 26/04/2012 Reason for notification Reoccurrence of a listed disease Date of
previous occurrence 2006 Manifestation of disease Sub-clinical infection Causal
agent Prion (atypical BSE) Nature of diagnosis Laboratory (advanced) This event
pertains to the whole country
New outbreaks Summary of outbreaks Total outbreaks: 1 Location(s)
CALIFORNIA (Tulare, County, Tulare, County) Total animals affected Species
Susceptible Cases Deaths Destroyed Slaughtered Cattle 1 1 0 Outbreak statistics
Species Apparent morbidity rate Apparent mortality rate Apparent case fatality
rate Proportion susceptible animals lost* Cattle ** ** ** **
* Removed from the susceptible population through death, destruction and/or
slaughter ** Not calculated because of missing information
Epidemiology Source of the outbreak(s) or origin of infection Unknown or
inconclusive Random mutation Epidemiological comments As part of the United
States targeted bovine spongiform encephalopathy (BSE) surveillance system a
case of BSE classified as atypical was identified in a dead dairy cow that was
to be rendered. The dead animal’s carcass will be destroyed. • The cow was
culled due to lameness. • The identified animal was never presented for
slaughter for human consumption, did not enter food supply channels, and at no
time presented any risk to human health. • An epidemiological investigation into
the incident has been initiated. • Movement controls have been placed on the
index premises.
Control measures Measures applied Quarantine Screening No vaccination No
treatment of affected animals Measures to be applied No other measures
Diagnostic test results Laboratory name and type University of California
(Local laboratory) Tests and results Species Test Test date Result Cattle
enzyme-linked immunosorbent assay (ELISA) 19/04/2012 Doubtful (uncertain)
Laboratory name and type National Veterinary Services Laboratories (NVSL)
(National laboratory) Tests and results Species Test Test date Result Cattle
enzyme-linked immunosorbent assay (ELISA) 21/04/2012 Doubtful (uncertain) Cattle
immunohistochemical test 23/04/2012 Positive Cattle western blotting 23/04/2012
Positive
Future Reporting The event is continuing. Weekly follow-up reports will be
submitted.
Encefalopatía espongiforme bovina, Estados Unidos de América
Información recibida el 26/04/2012 desde Dr John Clifford, Deputy
Administrator, Animal and Plant Health Inspection Service, United States
Department of Agriculture, Washington, Estados Unidos de América
Resumen
Tipo de informe Notificación inmediata Fecha de inicio 19/04/2012 Fecha de
la primera confirmación del evento 23/04/2012 Fecha del informe 26/04/2012 Fecha
de envio del informe a la OIE 26/04/2012 Motivo de la notificación Reaparición
de una enfermedad de la Lista de la OIE Fecha de la anterior aparición de la
enfermedad 2006 Manifestación de la enfermedad Infección sub-clínica Agente
causal Prion (EEB atípica) Naturaleza del diagnóstico Pruebas de diagnóstico de
laboratorio avanzadas (ej. virología, microscopía electrónica, biología
molecular e inmunología) Este evento concierne todo el país
Nuevos focos Resumen de los focos Número total de focos: 1 Localización
CALIFORNIA (Condado de Tulare, Tulare, County) Número total de animales
afectados Especies Susceptibles Casos Muertos Destruidos Sacrificados Bovinos 1
1 0 Estadística del foco Especies Tasa de morbilidad aparente Tasa de mortalidad
aparente Tasa de fatalidad aparente Proporción de animales susceptibles
perdidos* Bovinos ** ** ** **
* Descontados de la población susceptible a raíz de su muerte, destrucción
o sacrificio ** No calculado por falta de datos
Epidemiología Fuente del o de los focos u origen de la infección
Desconocida o no concluyente Mutación aleatoria Otros detalles epidemiológicos /
comentarios Dentro del sistema de vigilancia específica de los Estados Unidos
para la encefalopatía espongiforme bovina (EEB), se ha identificado un caso de
EEB clasificado como atípico en una vaca lechera muerta que debía ser destruida.
El cuerpo del animal muerto será destruido. - La vaca había sido sacrificada
porque cojeaba. - El animal identificado nunca fue enviado al matadero para
consumo humano, no entró en la cadena alimentaria y, en ningún momento, supuso
un riesgo para la salud humana. - Se ha emprendido una investigación
epidemiológica sobre el evento. - Se han instaurado medidas de restricción de
los desplazamientos en la explotación de origen.
Medidas de Control Medidas implementadas Cuarentena Tamizaje Vacunación: no
Ningún tratamiento de los animales afectados Medidas para implementar Ninguna
otra medida
Resultados de las pruebas diagnósticas Nombre y tipo de laboratorio
Universidad de California (Laboratorio local) Pruebas y resultados Especies
Prueba Fecha de la prueba Resultados Bovinos prueba inmunoenzimática (ELISA)
19/04/2012 Dudoso Nombre y tipo de laboratorio Laboratorio de los Servicios
veterinarios nacionales (NVSL) (Laboratorio nacional) Pruebas y resultados
Especies Prueba Fecha de la prueba Resultados Bovinos examen inmunohistoquímico
23/04/2012 Positivo Bovinos prueba de inmunodetección 23/04/2012 Positivo
Bovinos prueba inmunoenzimática (ELISA) 21/04/2012 Dudoso
Informes futuros El episodio continúa. Informes de seguimiento semanales
serán enviados
Encéphalopathie spongiforme bovine, Etats-Unis d'Amérique
Information reçue le 26/04/2012 de Dr John Clifford, Deputy Administrator,
Animal and Plant Health Inspection Service, United States Department of
Agriculture, Washington, Etats-Unis d'Amérique
Résumé
Type de rapport Notification immédiate Date de début 19/04/2012 Date de
première confirmation de l´événement 23/04/2012 Date du rapport 26/04/2012 Date
d'envoi à l'OIE 26/04/2012 Raison de notification Réapparition d’une maladie
appartenant à la liste de l'OIE Date de la précédente apparition de la maladie
2006 Manifestation de la maladie Infection sub-clinique Agent causal Prión (ESB
atypique) Nature du diagnostic Tests approfondis en laboratoire (i.e. virologie,
microscopie électronique, biologie moléculaire, immunologie) Cet événement se
rapporte à tout le pays
Nouveaux foyers Récapitulatif des foyers Nombre total de foyers : 1
Localisation(s) CALIFORNIA (Comté de Tulare, Tulare, County) Nombre total
d'animaux atteints Espèce(s) Sensibles Cas Morts Détruits Abattus Bovins 1 1 0
Statistiques sur le foyer Espèce(s) Taux de morbidité apparent Taux de mortalité
apparent Taux de fatalité apparent Proportion d'animaux sensibles perdus* Bovins
** ** ** **
* Soustraits de la population sensible suite à la mort, à l´abattage et/ou
à la destruction ** Non calculé par manque de données
Epidémiologie Source du/des foyer(s) ou origine de l´infection Inconnue ou
incertaine Mutation aléatoire Autres renseignements épidémiologiques /
Commentaires Dans le cadre du système de surveillance spécifique des États-Unis
pour l’encéphalopathie spongiforme bovine (ESB), un cas d’ESB classifié comme
atypique a été identifié chez une vache laitière morte devant être équarrie. La
carcasse de l’animal mort sera détruite. - La vache avait été abattue car elle
boitait. - L’animal identifié n’a jamais été envoyé à l’abattage pour
consommation par l’homme, il n’a pas été introduit dans la chaine alimentaire
et, à aucun moment, il n’a présenté aucun risque pour la santé humaine. - Une
enquête épidémiologique sur l’événement a été lancée. - Des mesures de
restriction des déplacements ont été mises en œuvre sur l’élevage d’origine.
Mesures de lutte Mesure de lutte appliquées Quarantaine Dépistage Pas de
vaccination Aucun traitement des animaux atteints Mesures à appliquer Aucune
autre mesure
Résultats des tests de diagnostics Nom du laboratoire et type Université de
Californie (Laboratoire local) Tests et résultats Espèce(s) Test Date du test
Résultat Bovins méthode de dosage immuno-enzymatique (ELISA) 19/04/2012 Douteux
Nom du laboratoire et type Laboratoire des Services vétérinaires nationaux
(NVSL) (Laboratoire national) Tests et résultats Espèce(s) Test Date du test
Résultat Bovins examen immunohistochimique 23/04/2012 Positif Bovins méthode de
dosage immuno-enzymatique (ELISA) 21/04/2012 Douteux Bovins western blot
23/04/2012 Positif
Rapports futurs Cet événement se poursuit. Des rapports de suivi
hebdomadaires devront être envoyés.
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Tuesday, July 17, 2012
O.I.E. BSE, CWD, SCRAPIE, TSE PRION DISEASE Final Report of the 80th
General Session, 20 - 25 May 2012
TSS
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